Document Detail

Nonfatal cancer preceding Parkinson's disease: a case-control study.
MedLine Citation:
PMID:  11880756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer. METHODS: We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, MN (1976-1995). Each case was matched by age and sex to a general population control. We ascertained cancer diagnoses through medical records abstraction. RESULTS: The frequency of any cancer was lower in cases (19.4%) than in controls (23.5%) (OR = 0.79; 95% CI = 0.49-1.27). This pattern was more pronounced in women than in men, and in patients age 71 years or younger at onset of PD than in older patients. We found an interaction between smoking and smoking-related cancers in their association with PD. Bladder cancer (OR = 0.22; 95% CI = 0.03-2.24) and breast cancer (OR = 0.20; 95% CI = 0.02-1.71) were less frequent in PD cases than in controls, whereas prostate cancer was more frequent in PD cases than in controls (OR = 1.80; 95% CI = 0.60-5.37). However, these results are based on small numbers. CONCLUSIONS: We did not find a strong association between PD and preceding nonfatal cancer. There were suggestive trends in analyses stratified by sex and age at onset of PD, and for specific cancers related to smoking or hormonal factors.
Alexis Elbaz; Brett J Peterson; Ping Yang; Jay A Van Gerpen; James H Bower; Demetrius M Maraganore; Shannon K McDonnell; J Eric Ahlskog; Walter A Rocca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  13     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-06     Completed Date:  2002-04-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
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MeSH Terms
Adenocarcinoma / epidemiology
Aged, 80 and over
Carcinoma, Squamous Cell / epidemiology
Case-Control Studies
Logistic Models
Middle Aged
Neoplasms / epidemiology*
Parkinson Disease / epidemiology*
Grant Support

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