| Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. | |
| | |
MedLine Citation:
|
PMID: 19755133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests. Exposure of rat fetuses to thalidomide (THAL) or valproic acid (VPA) on the ninth day of gestation has been reported as a useful model for human autism. We have shown that early serotonergic neural development is disrupted in these rats. In the current study, we used a radial maze and open field experimental paradigm to investigate whether these rats present behavioral and/or learning aberrations. THAL (500mg/kg), VPA (800mg/kg), or vehicle was administered orally to E9 pregnant rats at 7-10 weeks of age. Although the mean number of correct and incorrect arm choices in the initial eight arm choices did not differ between control and teratogen-exposed groups, achievement of learning (seven or eight consecutive correct choices for 3 consecutive days for individual rats) seemed to be impaired in teratogen-exposed groups. Interestingly, average time to explore the maze task was shorter in the teratogen-exposed groups, indicating that correct choice might be due to mere coincidence (i.e., nonexploratory movement). Unexpectedly, no significant differences were observed in social interaction in these rats. These results indicate that prenatal exposure to THAL and VPA might alter behavior in a manner that is, in part, consistent with human autism. |
| | |
Authors:
|
Masaaki Narita; Akiko Oyabu; Yoshio Imura; Naoki Kamada; Tomomi Yokoyama; Kaori Tano; Atsuko Uchida; Naoko Narita |
Related Documents
:
|
2804673 - Adaptation of the quantitative 2-[14c]deoxyglucose method for use in freely moving rats. 7250523 - Isolation has permanent effects upon the behavior of the rat, but not the mouse, gerbil... 4388243 - The effect of age and sex on glutathione reductase and glutathione peroxidase activitie... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-13 |
Journal Detail:
|
Title: Neuroscience research Volume: 66 ISSN: 1872-8111 ISO Abbreviation: Neurosci. Res. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-02-01 Completed Date: 2010-04-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: Ireland |
Other Details:
|
Languages: eng Pagination: 2-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
Affiliation:
|
Institute of Basic Medicine, University of Tsukuba, Japan. narita_m@doc.medic.mie-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Autistic Disorder / chemically induced*, physiopathology* Disease Models, Animal Exploratory Behavior / drug effects, physiology Female Interpersonal Relations Male Maze Learning / drug effects, physiology Pregnancy Prenatal Exposure Delayed Effects* Rats Thalidomide* Valproic Acid* |
| Chemical | |
Reg. No./Substance:
|
50-35-1/Thalidomide; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of red-spotted grouper nervous necrosis virus by loop-mediated isothermal amplification.
Next Document: Direct synaptic connections between superior colliculus afferents and thalamo-insular projection neu...