| Nonesterified fatty acids in the pathogenesis of hypertension: theory and evidence. | |
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MedLine Citation:
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PMID: 9250609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper approaches the hypothesis that fatty acids contribute to hypertension by examining possible interactions of nonesterified fatty acids with renal pressure-natriuresis, peripheral vascular resistance, and the central nervous barostat, three loci where long-term regulation of blood pressure is probably controlled. By inhibiting aldosterone secretion, nonesterified fatty acids may lower blood pressure by facilitating pressure-natriuresis. Oxygenated metabolites of fatty acids appear to stimulate aldosterone secretion. In different experimental situations, fatty acids either constrict or dilate arteries. There is no evidence of an effect of fatty acids on the central nervous barostat, but they do sensitize peripheral vessels to alpha-adrenergic stimuli. Obesity and diabetes are marked by increased incidence of hypertension, and elevated levels of fatty acids or their P450 oxygenated metabolites may contribute to this association. Drugs that influence plasma fatty acids, like heparin, do not have reproducible effects on blood pressure. Experimental evidence suggests but does not prove that nonesterified fatty acids can affect the long-term set-point of blood pressure. |
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Authors:
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T L Goodfriend; B M Egan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 57 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-10-01 Completed Date: 1997-10-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 57-63 Citation Subset: IM |
Affiliation:
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William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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secretion Animals Blood Pressure / physiology Fatty Acids, Nonesterified / blood, pharmacology, physiology* Homeostasis Humans Hypertension / etiology* Models, Biological* Natriuresis / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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R01-43164//PHS HHS; RR-01070/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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