Document Detail

Nonequilibrium mechanics of active cytoskeletal networks.
MedLine Citation:
PMID:  17234946     Owner:  NLM     Status:  MEDLINE    
Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate-dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation.
Daisuke Mizuno; Catherine Tardin; C F Schmidt; F C Mackintosh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  315     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-19     Completed Date:  2007-02-01     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-3     Citation Subset:  IM    
Department of Physics and Astronomy, Vrije Universiteit, 1081HV Amsterdam, Netherlands.
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MeSH Terms
Actins / physiology*
Adenosine Triphosphate / metabolism*
Cytoskeleton / physiology*
Microfilaments / physiology*
Models, Biological*
Molecular Motor Proteins / physiology*
Myosin Type II / physiology*
Stress, Mechanical
Reg. No./Substance:
0/Actins; 0/Molecular Motor Proteins; 56-65-5/Adenosine Triphosphate; EC 3.6.1.-/Myosin Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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