Document Detail

Nonendemic adult T-cell leukemia/lymphoma in the United States: report of two cases and review of the literature.
MedLine Citation:
PMID:  2981466     Owner:  NLM     Status:  MEDLINE    
Adult T-cell leukemia/lymphoma (ATLL) is a recently described distinct clinicopathologic entity characterized by a leukemic or lymphomatous proliferation of hyperlobulated peripheral T-cells, which is usually widespread at presentation and is associated with infection by a type C retrovirus. ATLL rarely is described outside of endemic regions, which include southwestern Japan, the Caribbean region, and the southeastern United States. The authors report the clinical, pathologic, and immunologic features of two cases of nonendemic ATLL that occurred in patients from the midwest United States. One patient was a 16-year-old white girl from rural Iowa, and the other was a 46-year-old white man from rural Minnesota. The features of 13 other probable nonendemic ATLL cases from the United States were compiled and reviewed. In the United States, nonendemic ATLL occurred in widespread geographic locations, affected mostly white people, and was characterized by an aggressive course with generalized adenopathy, blood and bone marrow involvement, and hepatosplenomegaly at presentation. Skin involvement was present in one-fourth of the patients. Hypercalcemia was rare. Although antibodies to type C retrovirus were detected in three of the five patients tested, the available data is not sufficient to establish a conclusive association between nonendemic ATLL and type C retrovirus infection.
K Foucar; T J Carroll; R Tannous; L Peterson; J A Goeken; S Binion; J Gajl-Peczalska; M E Kadin; W M Yokoyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  83     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-02-04     Completed Date:  1985-02-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-26     Citation Subset:  AIM; IM; X    
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MeSH Terms
Bone Marrow / pathology
Leukemia / epidemiology,  pathology
Leukocyte Count
Liver / pathology
Lymph Nodes / pathology
Middle Aged
Retroviridae Infections / complications
Spleen / pathology
United States

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