Document Detail


Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats.
MedLine Citation:
PMID:  14747679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer ((45)Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after (45)Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (V(bal)) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats.
Authors:
Tasleem A Zafar; Connie M Weaver; Yongdong Zhao; Berdine R Martin; Meryl E Wastney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  134     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-28     Completed Date:  2004-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-402     Citation Subset:  IM    
Affiliation:
Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Bone Resorption / metabolism*
Bone and Bones / metabolism*
Calcium / metabolism,  pharmacokinetics*
Digestion
Female
Oligosaccharides / administration & dosage,  pharmacology*
Ovariectomy
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Oligosaccharides; 7440-70-2/Calcium

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