| Nondepressant beta-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols. | |
| | |
MedLine Citation:
|
PMID: 31485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for beta-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12--15 were found to retain the beta-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent. |
| | |
Authors:
|
M E Condon; C M Cimarusti; R Fox; V L Narayanan; J Reid; J E Sundeen; F P Hauck |
Related Documents
:
|
22045925 - Effect of a telemonitoring-facilitated collaboration between general practitioner and h... 22424505 - Timing and technique of pulmonary valve replacement in the patient with tetralogy of fa... 21729325 - High sensitive troponin t and heart fatty acid binding protein: novel biomarker in hear... 6148005 - Coronary heart disease mortality/morbidity and risk in blacks. i: clinical manifestatio... 20181115 - Acute myocardial infarction as the first presentation of thyrotoxicosis in a 31-year ol... 9313605 - Increased plasma tissue factor levels in acute myocardial infarction. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Journal of medicinal chemistry Volume: 21 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1978 Sep |
Date Detail:
|
Created Date: 1979-02-26 Completed Date: 1979-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 913-22 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
chemical synthesis*,
pharmacology Animals Cats Epoxy Compounds Guinea Pigs Isoproterenol / antagonists & inhibitors Methods Myocardial Contraction / drug effects Phenols Propanolamines / chemical synthesis*, pharmacology Rats Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Epoxy Compounds; 0/Phenols; 0/Propanolamines; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stereoelectronic factors in the binding of substrate analogues and inhibitors to purine nucleoside p...
Next Document: Structure-activity study of beta-adrenergic agents using the SIMCA method of pattern recognition.