Document Detail

Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma.
MedLine Citation:
PMID:  20007338     Owner:  NLM     Status:  MEDLINE    
Chlorogenic acids (CGA) are antioxidants found in coffee. They are becoming of interest for their health-promoting effects, but bioavailability in humans is not well understood. We hypothesized that adding whole milk or sugar and nondairy creamer to instant coffee might modulate the bioavailability of coffee phenolics. Nine healthy participants were asked to randomly drink, in a crossover design, instant coffee (Coffee); instant coffee and 10% whole milk (Milk); or instant coffee, sugar, and nondairy creamer already premixed (Sugar/NDC). All 3 treatments provided the same amount of total CGA (332 mg). Blood was collected for 12 h after ingestion and plasma samples treated using a liquid-liquid extraction method that included a full enzymatic cleavage to hydrolyze all CGA and conjugates into phenolic acid equivalents. Hence, we focused our liquid chromatography-Electrospray ionization-tandem MS detection and quantification on caffeic acid (CA), ferulic acid (FA), and isoferulic acid (iFA) equivalents. Compared with a regular black instant coffee, the addition of milk did not significantly alter the area under the curve (AUC), maximum plasma concentration (C(max)), or the time needed to reach C(max) (T(max)). The C(max) of CA and iFA were significantly lower and the T(max) of FA and iFA significantly longer for the Sugar/NDC group than for the Coffee group. However, the AUC did not significantly differ. As a conclusion, adding whole milk did not alter the overall bioavailability of coffee phenolic acids, whereas sugar and nondairy creamer affected the T(max) and C(max) but not the appearance of coffee phenolics in plasma.
Mathieu Renouf; Cynthia Marmet; Philippe Guy; Anne-Lise Fraering; Karin Longet; Julie Moulin; Marc Enslen; Denis Barron; Christophe Cavin; Fabiola Dionisi; Serge Rezzi; Sunil Kochhar; Heike Steiling; Gary Williamson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-09
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  IM    
Nestlé Research Center, Vers chez Les Blancs, 1000 Lausanne 26, Switzerland.
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MeSH Terms
Antioxidants / pharmacokinetics
Area Under Curve
Biological Availability
Caffeic Acids / pharmacokinetics
Chromatography, High Pressure Liquid
Cinnamates / pharmacokinetics
Coffee / chemistry*
Coumaric Acids / pharmacokinetics
Cross-Over Studies
Dietary Fats / pharmacology*
Dietary Sucrose / pharmacology*
Phenols / pharmacokinetics*
Spectrometry, Mass, Electrospray Ionization
Reg. No./Substance:
0/Antioxidants; 0/Caffeic Acids; 0/Cinnamates; 0/Coffee; 0/Coumaric Acids; 0/Dietary Fats; 0/Dietary Sucrose; 0/Phenols; 1135-24-6/ferulic acid; 331-39-5/caffeic acid; 537-73-5/isoferulic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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