| Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma. | |
| | |
MedLine Citation:
|
PMID: 20007338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chlorogenic acids (CGA) are antioxidants found in coffee. They are becoming of interest for their health-promoting effects, but bioavailability in humans is not well understood. We hypothesized that adding whole milk or sugar and nondairy creamer to instant coffee might modulate the bioavailability of coffee phenolics. Nine healthy participants were asked to randomly drink, in a crossover design, instant coffee (Coffee); instant coffee and 10% whole milk (Milk); or instant coffee, sugar, and nondairy creamer already premixed (Sugar/NDC). All 3 treatments provided the same amount of total CGA (332 mg). Blood was collected for 12 h after ingestion and plasma samples treated using a liquid-liquid extraction method that included a full enzymatic cleavage to hydrolyze all CGA and conjugates into phenolic acid equivalents. Hence, we focused our liquid chromatography-Electrospray ionization-tandem MS detection and quantification on caffeic acid (CA), ferulic acid (FA), and isoferulic acid (iFA) equivalents. Compared with a regular black instant coffee, the addition of milk did not significantly alter the area under the curve (AUC), maximum plasma concentration (C(max)), or the time needed to reach C(max) (T(max)). The C(max) of CA and iFA were significantly lower and the T(max) of FA and iFA significantly longer for the Sugar/NDC group than for the Coffee group. However, the AUC did not significantly differ. As a conclusion, adding whole milk did not alter the overall bioavailability of coffee phenolic acids, whereas sugar and nondairy creamer affected the T(max) and C(max) but not the appearance of coffee phenolics in plasma. |
| | |
Authors:
|
Mathieu Renouf; Cynthia Marmet; Philippe Guy; Anne-Lise Fraering; Karin Longet; Julie Moulin; Marc Enslen; Denis Barron; Christophe Cavin; Fabiola Dionisi; Serge Rezzi; Sunil Kochhar; Heike Steiling; Gary Williamson |
Related Documents
:
|
15894038 - Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subc... 17958798 - Propionic acidemia manifesting with low isoleucine generalized exfoliative dermatosis. 15738238 - Use of odd and branched-chain fatty acids in rumen contents and milk as a potential mic... 8889628 - The effect of microwave heating on vitamins b1 and e, and linoleic and linolenic acids,... 10320358 - Conformational and amino acid residue requirements for the saposin c neuritogenic effect. 20448968 - Glycosyl-nucleoside-lipid based supramolecular assembly as a nanostructured material wi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-09 |
Journal Detail:
|
Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-21 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 259-63 Citation Subset: IM |
Affiliation:
|
Nestlé Research Center, Vers chez Les Blancs, 1000 Lausanne 26, Switzerland. mathieu.renouf@rdls.nestle.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Antioxidants / pharmacokinetics Area Under Curve Biological Availability Caffeic Acids / pharmacokinetics Chromatography, High Pressure Liquid Cinnamates / pharmacokinetics Coffee / chemistry* Coumaric Acids / pharmacokinetics Cross-Over Studies Dietary Fats / pharmacology* Dietary Sucrose / pharmacology* Female Humans Male Milk* Phenols / pharmacokinetics* Spectrometry, Mass, Electrospray Ionization |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Caffeic Acids; 0/Cinnamates; 0/Coffee; 0/Coumaric Acids; 0/Dietary Fats; 0/Dietary Sucrose; 0/Phenols; 1135-24-6/ferulic acid; 331-39-5/caffeic acid; 537-73-5/isoferulic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Consumption of a Flaxseed-Rich Food Is Not More Effective Than a Placebo in Alleviating the Climacte...
Next Document: A New Simulation Model Estimates Micronutrient Levels to Include in Fortified Blended Foods Used in ...