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Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload.
MedLine Citation:
PMID:  25104503     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To explore the use and reproducibility of magnetic resonance-derived myocardial T1 mapping in patients with iron overload.
MATERIALS AND METHODS: The research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty-five patients underwent repeat scanning for reproducibility. T1 mapping used the shortened modified Look-Locker inversion recovery sequence (ShMOLLI) with a second, confirmatory MOLLI sequence in the reproducibility group. T2 * was performed using a commercially available sequence. The analysis of the T2 * interstudy reproducibility data was performed by two different research groups using two different methods.
RESULTS: Myocardial T1 was lower in patients than healthy volunteers (836 ± 138 msec vs. 968 ± 32 msec, P < 0.0001). Myocardial T1 correlated with T2 * (R = 0.79, P < 0.0001). No patient with low T2 * had normal T1 , but 32% (n = 28) of cases characterized by a normal T2 * had low myocardial T1 . Interstudy reproducibility of either T1 sequence was significantly better than T2 *, with the results suggesting that the use of T1 in clinical trials could decrease potential sample sizes by 7-fold.
CONCLUSION: Myocardial T1 mapping is an alternative method for cardiac iron quantification. T1 mapping shows the potential for improved detection of mild iron loading. The superior reproducibility of T1 has potential implications for clinical trial design and therapeutic monitoring. J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc.
Authors:
Daniel M Sado; Viviana Maestrini; Stefan K Piechnik; Sanjay M Banypersad; Steven K White; Andrew S Flett; Matthew D Robson; Stefan Neubauer; Cono Ariti; Andrew Arai; Peter Kellman; Jin Yamamura; Bjoern P Schoennagel; Farrukh Shah; Bernard Davis; Sara Trompeter; Malcolm Walker; John Porter; James C Moon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-8
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  -     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc.
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