Document Detail


Noncontrast dynamic MRA in intracranial arteriovenous malformation (AVM), comparison with time of flight (TOF) and digital subtraction angiography (DSA).
MedLine Citation:
PMID:  22521994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Digital subtraction angiography (DSA) remains the gold standard to diagnose intracranial arteriovenous malformations (AVMs) but is invasive. Existing magnetic resonance angiography (MRA) is suboptimal for assessing the hemodynamics of AVMs. The objective of this study was to evaluate the clinical utility of a novel noncontrast four-dimensional (4D) dynamic MRA (dMRA) in the evaluation of intracranial AVMs through comparison with DSA and time-of-flight (TOF) MRA. Nineteen patients (12 women, mean age 26.2±10.7 years) with intracranial AVMs were examined with 4D dMRA, TOF and DSA. Spetzler-Martin grading scale was evaluated using each of the above three methods independently by two raters. Diagnostic confidence scores for three components of AVMs (feeding artery, nidus and draining vein) were also rated. Kendall's coefficient of concordance was calculated to evaluate the reliability between two raters within each modality (dMRA, TOF, TOF plus dMRA). The Wilcoxon signed-rank test was applied to compare the diagnostic confidence scores between each pair of the three modalities. dMRA was able to detect 16 out of 19 AVMs, and the ratings of AVM size and location matched those of DSA. The diagnostic confidence scores by dMRA were adequate for nidus (3.5/5), moderate for feeding arteries (2.5/5) and poor for draining veins (1.5/5). The hemodynamic information provided by dMRA improved diagnostic confidence scores by TOF MRA. As a completely noninvasive method, 4D dMRA offers hemodynamic information with a temporal resolution of 50-100 ms for the evaluation of AVMs and can complement existing methods such as DSA and TOF MRA.
Authors:
Songlin Yu; Lirong Yan; Yuqiang Yao; Shuo Wang; Mingqi Yang; Bo Wang; Yan Zhuo; Lin Ai; Xinyuan Miao; Jizong Zhao; Danny J J Wang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-20
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  30     ISSN:  1873-5894     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-10-03     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  869-77     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiography, Digital Subtraction*
Female
Humans
Intracranial Arteriovenous Malformations / diagnosis*,  radiography
Magnetic Resonance Angiography*
Magnetic Resonance Imaging / methods*
Male
Grant Support
ID/Acronym/Agency:
MH080892/MH/NIMH NIH HHS; R01 EB014922/EB/NIBIB NIH HHS; R01 MH080892/MH/NIMH NIH HHS; R01 NS081077/NS/NINDS NIH HHS
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