Document Detail

Noncontact mapping-guided catheter ablation of atrial fibrillation.
MedLine Citation:
PMID:  19060418     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An alternative approach to complete isolation of the posterior left atrium (LA), including all pulmonary veins (PVs), for treating atrial fibrillation (AF) is the Box isolation. However, it is sometimes difficult to confirm the conduction block within the linear lesion lines, so in the present study the efficacy of the Box isolation guided by noncontact mapping (NCM) was evaluated. METHODS AND RESULTS: A total of 188 patients, 116 with paroxysmal, 48 with persistent and 24 with longstanding persistent AF, underwent the Box isolation using NCM system. The endpoint was defined as bi-directional conduction block in the posterior LA confirmed by an activation map using NCM during pacing inside and outside of the posterior LA. The induced atrial tachyarrhythmias and non-PV foci were also ablated using NCM. After 12+/-4 months of follow-up, 91% of the patients with paroxysmal AF, 73% of those with persistent AF and 46% with longstanding persistent AF were arrhythmia-free without drugs. CONCLUSIONS: NCM is useful for defining complete Box isolation and detecting the conduction gaps, localizing non-PV foci, and analyzing the mechanism of atrial tachyarrhythmias. NCM-guided Box isolation is a feasible, safe and effective method of treating AF.
Koichiro Kumagai; Hideko Nakashima
Related Documents :
17670298 - Prophylactic amiodarone effectively prevents post-operative atrial fibrillation.
16473788 - Atrial distribution of connexin 40 and 43 in patients with intermittent, persistent, an...
8041858 - Is the high ischemic heart disease mortality rate in new york state just an urban effect?
9846808 - Effects of a cardioselective m2 receptor antagonist, af-dx 116, on ventricular arrhythm...
25124378 - Angioedema related to angiotensin inhibitors.
23771988 - The prognostic value of normal stress cardiac magnetic resonance in patients with known...
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-12-08
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
International University of Health and Welfare, Fukuoka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Atrial Fibrillation / physiopathology*,  surgery*
Catheter Ablation / adverse effects,  methods*
Electrophysiological Phenomena
Endpoint Determination
Heart Atria / physiopathology,  surgery,  ultrasonography
Heart Conduction System / physiopathology*
Middle Aged
Pulmonary Veins / physiopathology
Comment In:
Circ J. 2009 Feb;73(2):227-8   [PMID:  19164859 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhi...
Next Document:  Optimal treatment strategy for patients with paroxysmal atrial fibrillation: J-RHYTHM Study.