| Noncongophilic fibrillary glomerulonephritis in a cat. | |
| | |
MedLine Citation:
|
PMID: 18487491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This report describes an uncommon case of nonamyloidotic fibrillary glomerulonephritis. A 5-year-old female European cat was presented with nephrotic syndrome. Serum biochemistry and urinalysis revealed a mild increase in cholesterol, low total protein, severe hypoalbuminemia, and high proteinuria with a high protein-to-creatinine ratio. An histologic examination revealed an interstitial nephritis and a diffuse glomerulonephritis, with multifocal thickening of the Bowman's capsule. Transmission electron microscopy showed widespread fibrillary deposits in the glomerular basement membrane and in the mesangium. These fibrils ranged between 18 and 26 nm in diameter and were Congo red negative, which allowed their differentiation from amyloid. Immunohistochemistry demonstrated expression for immunoglobulin M (IgM) and immunoglobulin G (IgG) within the mesangium. Renal deposits of Congo red-negative amyloid-like fibrils have been described in humans, horses, monkeys, and dogs. This is the first report of noncongophilic fibrillary glomerulopathy in a cat. |
| | |
Authors:
|
P Cavana; M T Capucchio; A Bovero; D Ripanti; D Catalano; F E Scaglione; J Miller; T Blunden; A M Farca |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Veterinary pathology Volume: 45 ISSN: 0300-9858 ISO Abbreviation: Vet. Pathol. Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-05-19 Completed Date: 2008-09-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 347-51 Citation Subset: IM |
Affiliation:
|
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Turin, Turin, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cat Diseases / pathology* Cats Female Glomerular Basement Membrane / pathology Glomerulonephritis / veterinary* Immunoglobulin G / analysis Kidney / immunology, pathology Ovariectomy / veterinary |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Necrotizing meningoencephalitis in five Chihuahua dogs.
Next Document: Cutaneous and nasal protothecosis in a goat.