Document Detail


Noncompaction and endocarditis in suspected mitochondrial disorder.
MedLine Citation:
PMID:  17303269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To report the echocardiographic and autopsy findings of left ventricular hypertrabeculation (LVHT), also known as noncompaction, in a patient with central and peripheral nervous system disease, who died shortly after diagnosing noncompaction. CASE REPORT: In a 75 year old woman with cognitive decline, Parkinson syndrome, stroke-like-episodes, basal ganglia calcification, neuromuscular disorder, cataract, diabetes, anemia, arterial hypertension, recurrent heart failure, left anterior hemiblock, and right bundle branch block, acute heart failure developed during treatment of a suspected urosepsis. Transthoracic echocardiography revealed severely reduced fractional shortening, valvular vegetations, and LVHT. Endocarditis was suspected. She died shortly afterwards from renal failure and ventricular fibrillation. Endocarditis and LVHT were confirmed at autopsy. CONCLUSIONS: This case shows that endocarditis may occur together with LVHT and central and peripheral nervous system disease indicative of a mitochondrial disorder. Whether LVHT predisposes for endocarditis remains speculative.
Authors:
Josef Finsterer; Claudia Stöllberger; Hans Feichtinger
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Publication Detail:
Type:  Case Reports; Letter     Date:  2007-02-14
Journal Detail:
Title:  International journal of cardiology     Volume:  123     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e45-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Autopsy
Central Nervous System Diseases / complications,  pathology*,  ultrasonography
Echocardiography, Transesophageal
Endocarditis / complications,  pathology*,  ultrasonography
Fatal Outcome
Female
Heart Failure / complications,  pathology*,  ultrasonography
Humans
Hypertrophy, Left Ventricular / complications,  pathology*,  ultrasonography
Mitochondria / pathology*,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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