Document Detail


Nonclassic adrenal hyperplasia due to 21-hydroxylase deficiency.
MedLine Citation:
PMID:  3302893     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonclassic adrenal hyperplasia due to 21-hydroxylase deficiency (21-OHD) is an autosomal recessive disorder distinguished from classic 21-OHD by clinical and hormonal criteria. It is most often described as a disorder of adrenal steroidogenesis with onset of virilization in late childhood, peripubertally or postpubertally. An overview of adrenal steroidogenesis is presented elsewhere in this publication. It is the aim of this article to focus on the clinical and hormonal manifestations of the disorder, with discussion of the current methods of diagnosis and management. Recent advances in classic and molecular genetics will follow.
Authors:
S Drucker; M I New
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pediatric clinics of North America     Volume:  34     ISSN:  0031-3955     ISO Abbreviation:  Pediatr. Clin. North Am.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-02     Completed Date:  1987-09-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401126     Medline TA:  Pediatr Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1067-81     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Hyperplasia, Congenital* / etiology,  genetics
Female
Glucocorticoids / therapeutic use
HLA Antigens / genetics
Heterozygote Detection
Humans
Pedigree
Steroid Hydroxylases / deficiency*
Grant Support
ID/Acronym/Agency:
R01 HD 00072/HD/NICHD NIH HHS; R01 HL 17749/HL/NHLBI NIH HHS; RR47/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/HLA Antigens; EC 1.14.-/Steroid Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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