| Noncirrhotic portal hypertension in patients with human immunodeficiency virus-1 infection. | |
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MedLine Citation:
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PMID: 18639498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Noncirrhotic portal hypertension (NCPH) is unusual in North American patients. This study characterized patients with NCPH and human immunodeficiency virus-1 (HIV-1) infection to identify potential risk factors for this association. METHODS: Eleven consecutive patients from our urban hepatology clinic with HIV-1 infection and NCPH were the subject of this series. Case histories, including medication lists and laboratory data, were analyzed. RESULTS: Age at diagnosis was 51 +/- 7 years. CD4 count was 303 +/- 185 cells/mL, and HIV viral load was <75 copies/mL in 9 patients. Didanosine was the only medication taken by all patients; 10 each had taken lamivudine and zidovudine. In the 10 patients tested, 8 had at least 1 thrombophilic abnormality; 6 were deficient in protein S, and 2 had multiple abnormalities. Nodular regenerative hyperplasia was observed in all 11 and portal venulopathy in 5 patients. All patients had esophageal varices; 3 developed variceal bleeding. Six patients had ascites; 2 required transjugular intrahepatic portal systemic shunt. CONCLUSIONS: Exposure to didanosine and/or a hypercoagulable tendency might predispose patients infected with HIV-1 to vascular changes resulting in NCPH. |
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Authors:
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Sophia Saifee; Dean Joelson; James Braude; Roshan Shrestha; Mark Johnson; Marty Sellers; Michael R Galambos; Raymond A Rubin |
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Publication Detail:
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Type: Journal Article Date: 2008-07-17 |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 6 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: 1167-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Atlanta Medical Center, Atlanta, Georgia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-HIV Agents / therapeutic use CD4 Lymphocyte Count Didanosine / therapeutic use Female HIV Infections / complications*, drug therapy, virology* HIV-1 / isolation & purification* Humans Hypertension, Portal / etiology* Lamivudine / therapeutic use Male Middle Aged Risk Factors Thrombophilia Viral Load Zidovudine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 134678-17-4/Lamivudine; 30516-87-1/Zidovudine; 69655-05-6/Didanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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