Document Detail


Noncationic dipeptide mimic oligomers as cell penetrating nonpeptides (CPNP).
MedLine Citation:
PMID:  20815388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small oligomers of constrained dipeptide mimics have been synthesized as new vectors for intracellular delivery. They are highly internalized by cells and delivered to the lysosomes by an energy-dependent pathway. This new class of vectors referred to as cell penetrating nonpeptides (CPNP) possess the distinctive feature of being noncationic.
Authors:
Lubomir L Vezenkov; Marie Maynadier; Jean-François Hernandez; Marie-Christine Averlant-Petit; Olivier Fabre; Ettore Benedetti; Marcel Garcia; Jean Martinez; Muriel Amblard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioconjugate chemistry     Volume:  21     ISSN:  1520-4812     ISO Abbreviation:  Bioconjug. Chem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-20     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010319     Medline TA:  Bioconjug Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1850-4     Citation Subset:  IM    
Affiliation:
Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Universités Montpellier 1 et 2, Montpellier, France.
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MeSH Terms
Descriptor/Qualifier:
Biological Transport
Cell Line, Tumor
Dipeptides / chemistry*
Humans
Intracellular Space / metabolism
Peptidomimetics / chemistry*,  metabolism*
Polymers / chemistry,  metabolism
Thiazepines / chemistry
Chemical
Reg. No./Substance:
0/Dipeptides; 0/Peptidomimetics; 0/Polymers; 0/Thiazepines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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