| Nonbacterial thrombotic endocarditis as a cause of cerebral and myocardial infarction. | |
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MedLine Citation:
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PMID: 6481938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinicopathologic correlations of nonbacterial thrombotic endocarditis (NBTE) were studied with special reference to their pathogenetic role in cerebral and myocardial infarction. In 2340 cases of consecutive autopsies of the aged, NBTE was observed in 217 cases or 9.3%. The age distribution of NBTE revealed a gradual increase with advancing age. The underlying diseases of NBTE were malignant neoplasm (51.6%), infection (28.3%) and other diseases (20.1%). The incidence of NBTE in each cancer was high in cancers of the colon (16.2%), pancreas (15.2%), gall bladder or bile duct (14.1%) and lung (13.0%). The vegetations of NBTE were found on the aortic valve in 46.1%, on the mitral valve in 40.6% and on the both valves in 8.3%. The incidence of myocardial infarction and scar was 51.2% in the NBTE group, while it was 38.6% in the non-NBTE control group (p less than 0.02). This difference was marked in patients with a small infarction (10.6% vs. 5.3%) and a myocardial scar (30.4% vs. 19.0%). The grade of coronary stenosis was less in the NBTE group than in the control group (p less than 0.001), suggesting that the origin of the myocardial ischemic lesion was embolism from NBTE. The incidence of large cerebral infarction was 14.7% in NBTE and 9.2% in the control group, and that of medium sized cerebral infarction was 35.0% and 23.6% respectively. In this latter group, cortical infarction comprised 57.9% in the NBTE group and 26.6% in the control group. In large cerebral infarction, cerebral atherosclerosis was less severe in NBTE than in the control group (p less than 0.001), also suggesting an embolic mechanism. Disseminated intravascular coagulation was found in 41.9% of NBTE.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K Kuramoto; S Matsushita; H Yamanouchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese circulation journal Volume: 48 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-11-06 Completed Date: 1984-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1000-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cerebral Infarction / epidemiology, etiology* Disseminated Intravascular Coagulation / complications* Endocarditis / complications* Female Humans Japan Male Middle Aged Myocardial Infarction / epidemiology, etiology* Neoplasms / complications Thrombosis / complications* |
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