Document Detail

Nonarteritic anterior ischemic optic neuropathy with PDE-5 inhibitors for erectile dysfunction.
MedLine Citation:
PMID:  18528398     Owner:  NLM     Status:  MEDLINE    
Phosphodiesterase type-5 (PDE-5) inhibitors are well tolerated and efficacious treatments for male erectile dysfunction that currently rank among the best-selling drugs worldwide. Since their introduction 10 years ago, there have been a number of reports of patients developing, within hours of PDE-5 inhibitor use, permanent visual loss due to nonarteritic anterior ischemic optic neuropathy (NAION), a common optic neuropathy that results from ischemia of the optic nerve head. In some of the cases, visual loss recurred upon rechallenge with the drug. However, as the bulk of the evidence suggesting a relationship between PDE-5 inhibitor use and NAION comes from case reports and small series, it is difficult to ascertain if a cause-effect relationship truly exists. In this paper, following a review of the transient visual side effects of PDE-5 inhibitors and NAION, we discuss the evidence for and against NAION occurring as a complication of PDE-5 inhibitor use.
M J Thurtell; R L Tomsak
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-05
Journal Detail:
Title:  International journal of impotence research     Volume:  20     ISSN:  1476-5489     ISO Abbreviation:  Int. J. Impot. Res.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007383     Medline TA:  Int J Impot Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  537-43     Citation Subset:  IM    
Department of Neurology, Division of Neuro-Ophthalmology, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.
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MeSH Terms
Arteries / drug effects
Cyclic Nucleotide Phosphodiesterases, Type 5 / antagonists & inhibitors*,  metabolism
Erectile Dysfunction / drug therapy*,  enzymology*
Optic Neuropathy, Ischemic / chemically induced*,  pathology
Phosphodiesterase Inhibitors / adverse effects*,  therapeutic use*
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; EC Nucleotide Phosphodiesterases, Type 5

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