Document Detail


Nonallergen-specific treatments for food allergy.
MedLine Citation:
PMID:  22475999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This review summarizes recent reports on nonallergen-specific therapies for food allergy. These therapies are especially appealing for food allergy because unlike allergen-specific immunotherapy, they would allow the treatment of multiple food allergies in a single patient with one therapy.
RECENT FINDINGS: Chinese herbal therapy, anti-IgE, probiotics, engineered lactic acid bacteria, and helminth therapy are all examples of allergen nonspecific therapies that have been investigated in recent years. Although some have only been studied in animal models of food allergy, some are undergoing rigorous, human clinical trials.
SUMMARY: Increasing amounts of research are examining the efficacy and safety of nonallergen-specific therapies for food allergy. There is hope that clinicians will have effective treatments either as an alternative or as an adjunct to immunotherapy.
Authors:
Jay A Lieberman; Julie Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  12     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-08-27     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-301     Citation Subset:  IM    
Affiliation:
Division of Allergy and Immunology, Department of Pediatrics, Elliot and Roslyn Jaffe Food Allergy Institute, Mount Sinai School of Medicine, Manhattan, New York City, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Allergic Agents / therapeutic use*
Antibodies, Anti-Idiotypic / therapeutic use*
Antibodies, Monoclonal, Humanized / therapeutic use*
Clinical Trials as Topic
Disease Models, Animal
Drugs, Chinese Herbal / therapeutic use*
Food Hypersensitivity / drug therapy*,  etiology,  immunology,  therapy*
Humans
Infant
Mice
Probiotics / therapeutic use*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
AI083883/AI/NIAID NIH HHS; K23 AI083883/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Allergic Agents; 0/Antibodies, Anti-Idiotypic; 0/Antibodies, Monoclonal, Humanized; 0/Drugs, Chinese Herbal; 0/omalizumab

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