Document Detail

Nonalcoholic fatty liver disease (NAFLD): a comprehensive review.
MedLine Citation:
PMID:  15104027     Owner:  NLM     Status:  MEDLINE    
Nonalcoholic fatty liver disease (NAFLD) is defined as fatty infiltration of the liver exceeding 5% to 10% by weight. It is a spectrum of disorders ranging from simple fatty liver (steatosis without liver injury), nonalcoholic steatohepatitis (steatosis with inflammation), and fibrosis/cirrhosis that resembles alcohol-induced liver disease but which develops in individuals who are not heavy drinkers. NAFLD is likely the most common cause of chronic liver disease in many countries. NAFLD may also potentiate liver damage induced by other agents, such as alcohol, industrial toxins and hepatatrophic viruses. The lack of specific and sensitive noninvasive tests for NAFLD limits reliable detection of the disease. It is often diagnosed on a presumptive basis when liver enzyme elevations are noted in overweight or obese individuals without identifiable etiology for liver disease, or when imaging studies suggest hepatic steatosis. NAFLD is now considered to be a component of the insulin resistance syndrome (metabolic syndrome X). Controversy exists relative to optimal recognition, diagnosis and management of these conditions, and treatment recommendations are evolving.
William B Salt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of insurance medicine (New York, N.Y.)     Volume:  36     ISSN:  0743-6661     ISO Abbreviation:  J Insur Med     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-23     Completed Date:  2004-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8401468     Medline TA:  J Insur Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-41     Citation Subset:  T    
Ohio State University, Columbus, Ohio, USA.
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MeSH Terms
Biopsy, Needle
Chronic Disease
Diagnosis, Differential
Disease Progression
Fat Necrosis / etiology
Fatty Liver* / complications,  drug therapy,  metabolism,  pathology
Hepatitis / etiology
Insurance, Life
Liver / pathology
Metabolic Syndrome X / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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