Document Detail

Nonalcoholic fatty liver disease and HIV infection.
MedLine Citation:
PMID:  16970837     Owner:  NLM     Status:  MEDLINE    
As persons with HIV live longer, chronic liver disease is increasingly important. Nonalcoholic fatty liver disease (NAFLD) is characterized by excess fat in hepatocytes in patients without significant alcohol use. It can progress from steatosis to nonalcoholic steatohepatitis (NASH) to cirrhosis. Visceral obesity and insulin resistance are integral to the pathogenesis of NAFLD. Patients with HIV are at greater risk of NAFLD due to antiretroviral therapy and viral hepatitis coinfection. Antiretroviral therapy can lead to patterns of injury that include steatosis and NASH. Coinfection with hepatitis C virus increases the risk of insulin resistance and hepatic steatosis, and co-existent features of NASH have also been reported. Histological-based, longitudinal studies are needed that address the interactions of NAFLD and HIV infection, the effects of antiretroviral therapy and hepatotropic virus coinfection, and inform better management strategies.
Raphael B Merriman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current HIV/AIDS reports     Volume:  3     ISSN:  1548-3568     ISO Abbreviation:  -     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235661     Medline TA:  Curr HIV/AIDS Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Division of Gastroenterology, Department of Medicine, 513 Parnassus Avenue, Room S-357, University of California, San Francisco, CA 94143-0538, USA.
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MeSH Terms
Fatty Liver / epidemiology,  etiology*
HIV Infections / complications*
Insulin Resistance
Liver Cirrhosis / etiology
Obesity / complications

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