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Nonalcoholic Fatty Liver Disease Contributes to Hepatocellular Carcinoma in Non-cirrhotic Liver: A Clinical and Pathological Study.
MedLine Citation:
PMID:  23302015     Owner:  NLM     Status:  Publisher    
Hepatocellular carcinoma (HCC) is a major complication of cirrhosis and has been increasing in incidence in recent years. Fatty liver disease is an increasingly common cause of chronic liver disease, and there have been several case reports of HCC in patients with non-cirrhotic fatty liver disease. However, there is limited data from systematic studies with histological confirmation of the presence of both the HCC and the non-cirrhotic fatty liver disease. We studied the occurrence of fatty liver disease and the associated demographic, clinical and pathological characteristics of a large cohort of patients with HCC in non-cirrhotic livers. Patients with intrahepatic cholangiocarcinoma (CC) occurring in non-cirrhotic livers and diagnosed during the same time period was used as the comparison group. Significant steatosis in the non-tumor liver had a statistically significant association with HCC, being present in 54% (85/157) of HCC, compared to 27% (32/120) of CC (p<0.0001). Steatohepatitis was present in 15% (24/157) of HCC and 1% (2/120) of CC (p=0.0014). Furthermore, HCC was more prevalent in cases with higher grades of steatosis. In addition, the recently described intra-tumoral steatohepatitic morphology of HCC (SH-HCC) was also associated with significant steatosis in non-tumor liver, with significant steatosis being present in 89% with SH-HCC, compared to 50% without SH-HCC (p=0.0162). Finally, SH-HCC was increasingly more prevalent in patients with higher grades of non-tumor steatosis. Taken together, these findings suggest a strong association between fatty liver disease and HCC in non-cirrhotic livers.
Jacob Alexander; Michael Torbenson; Tsung-Teh Wu; Matthew M Yeh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Division of Gastroenterology, Department of Internal Medicine, University of Washington School of Medicine, Seattle, WA.
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