| Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. | |
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MedLine Citation:
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PMID: 19682117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare the risk of mortality of nonagenarian siblings with that of sporadic nonagenarians (not selected on having a nonagenarian sibling) and to compare the prevalence of morbidity in their offspring with that of the offsprings' partners. DESIGN: Longitudinal (mortality risk) and cross-sectional (disease prevalence). SETTING: Nationwide sample. PARTICIPANTS: The Leiden Longevity Study consists of 991 nonagenarian siblings derived from 420 Caucasian families, 1,365 of their offspring, and 621 of the offsprings' partners. In the Leiden 85-plus Study, 599 subjects aged 85 were included, of whom 275 attained the age of 90 (sporadic nonagenarians). MEASUREMENTS: All nonagenarian siblings and sporadic nonagenarians were followed for mortality (with a mean+/-standard deviation follow-up time of 2.7+/-1.4 years and 3.0+/-1.5 years, respectively). Information on medical history and medication use was collected for offspring and their partners. RESULTS: Nonagenarian siblings had a 41% lower risk of mortality (P<.001) than sporadic nonagenarians. The offspring of nonagenarian siblings had a lower prevalence of myocardial infarction (2.4% vs 4.1%, P=.03), hypertension (23.0% vs 27.5%, P=.01), diabetes mellitus (4.4% vs 7.6%, P=.004), and use of cardiovascular medication (23.0% vs 28.9%, P=.003) than their partners. CONCLUSION: The lower mortality rate of nonagenarian siblings and lower prevalence of morbidity in their middle-aged offspring reinforce the notion that resilience against disease and death have similar underlying biology that is determined by genetic or familial factors. |
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Authors:
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Rudi G J Westendorp; Diana van Heemst; Maarten P Rozing; Marijke Frölich; Simon P Mooijaart; Gerard-Jan Blauw; Marian Beekman; Bastiaan T Heijmans; Anton J M de Craen; P Eline Slagboom; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-17 |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 57 ISSN: 1532-5415 ISO Abbreviation: J Am Geriatr Soc Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-11-09 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: United States |
Other Details:
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Languages: eng Pagination: 1634-7 Citation Subset: IM |
Affiliation:
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Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. r.g.j.westendorp@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over
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statistics & numerical data* Cardiovascular Agents / therapeutic use Cause of Death Cross-Sectional Studies Diabetes Mellitus / mortality Female Follow-Up Studies Health Surveys Humans Hypertension / mortality Longevity / genetics* Longitudinal Studies Male Morbidity* Mortality* Myocardial Infarction / mortality Netherlands Phenotype Proportional Hazards Models Prospective Studies Risk Siblings |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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