Document Detail

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.
MedLine Citation:
PMID:  19682117     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the risk of mortality of nonagenarian siblings with that of sporadic nonagenarians (not selected on having a nonagenarian sibling) and to compare the prevalence of morbidity in their offspring with that of the offsprings' partners. DESIGN: Longitudinal (mortality risk) and cross-sectional (disease prevalence). SETTING: Nationwide sample. PARTICIPANTS: The Leiden Longevity Study consists of 991 nonagenarian siblings derived from 420 Caucasian families, 1,365 of their offspring, and 621 of the offsprings' partners. In the Leiden 85-plus Study, 599 subjects aged 85 were included, of whom 275 attained the age of 90 (sporadic nonagenarians). MEASUREMENTS: All nonagenarian siblings and sporadic nonagenarians were followed for mortality (with a mean+/-standard deviation follow-up time of 2.7+/-1.4 years and 3.0+/-1.5 years, respectively). Information on medical history and medication use was collected for offspring and their partners. RESULTS: Nonagenarian siblings had a 41% lower risk of mortality (P<.001) than sporadic nonagenarians. The offspring of nonagenarian siblings had a lower prevalence of myocardial infarction (2.4% vs 4.1%, P=.03), hypertension (23.0% vs 27.5%, P=.01), diabetes mellitus (4.4% vs 7.6%, P=.004), and use of cardiovascular medication (23.0% vs 28.9%, P=.003) than their partners. CONCLUSION: The lower mortality rate of nonagenarian siblings and lower prevalence of morbidity in their middle-aged offspring reinforce the notion that resilience against disease and death have similar underlying biology that is determined by genetic or familial factors.
Rudi G J Westendorp; Diana van Heemst; Maarten P Rozing; Marijke Frölich; Simon P Mooijaart; Gerard-Jan Blauw; Marian Beekman; Bastiaan T Heijmans; Anton J M de Craen; P Eline Slagboom;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-17
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  57     ISSN:  1532-5415     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1634-7     Citation Subset:  IM    
Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.
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MeSH Terms
Aged, 80 and over / statistics & numerical data*
Cardiovascular Agents / therapeutic use
Cause of Death
Cross-Sectional Studies
Diabetes Mellitus / mortality
Follow-Up Studies
Health Surveys
Hypertension / mortality
Longevity / genetics*
Longitudinal Studies
Myocardial Infarction / mortality
Proportional Hazards Models
Prospective Studies
Reg. No./Substance:
0/Cardiovascular Agents

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