| Nonablative fractional resurfacing in combination with topical tretinoin cream as a field treatment modality for multiple actinic keratosis: a pilot study and a review of other field treatment modalities. | |
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MedLine Citation:
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PMID: 22515664 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background: Actinic keratosis (AK) are premalignant lesions occurring mainly in sun-damaged skin. Current topical treatment options for AK and photo damaged skin such as liquid nitrogen and electro surgery are not suitable for field treatment. Otherwise, therapies suitable for field treatment bring along considerable patient discomfort. Nonablative fractional resurfacing has emerged as a logical treatment option especially for field treatment of AK. Objectives: - To evaluate the clinical efficacy of fractional laser therapy for clearing AK and improving skin quality. - To compare patient friendliness of the "fractional" therapy with those reported for other field treatment modalities. Materials & Methods: Ten patients with Fitzpatrick I to III type skin with multiple actinic keratoses and extensive sun-damaged skin, received 5 to 10 sessions with a 4-week interval using a 1550 nm Erbium-Glass Fractionated laser (Sellas, Korea). Four weeks and 24 weeks after the last treatment the clinical results were evaluated by an independent physician. Results: The mean degree of improvement, in terms of reduction in the number of AK and improvement of skin texture, was 54% on a 4 point PGA scale, and persisted for approximately 6 months. The biggest advantage of fractional laser treatment, besides the eradication of AK and a clear rejuvenation effect, is the absence of "down time". Conclusion: Fractional nonablative resurfacing induces significant reduction in the number of AK and improves the skin quality. Also all patients preferred fractional laser therapy above other AK treatment modalities. |
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Authors:
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Sebastiaan P Prens; Karin de Vries; Martino H A Neumann; Errol P Prens |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-19 |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: - ISSN: 1471-1753 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Erasmus MC, Universtity Medical Center Rotterdam , The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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