Document Detail

Non-ablative fractional resurfacing in combination with topical tretinoin cream as a field treatment modality for multiple actinic keratosis: a pilot study and a review of other field treatment modalities.
MedLine Citation:
PMID:  22515664     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Actinic keratoses (AK) are premalignant lesions occurring mainly in sun-damaged skin. Current topical treatment options for AK and photo-damaged skin such as liquid nitrogen and electrosurgery are not suitable for field treatment. Otherwise, therapies suitable for field treatment bring along considerable patient discomfort. Non-ablative fractional resurfacing has emerged as a logical treatment option especially for field treatment of AK.
OBJECTIVES: To evaluate the clinical efficacy of fractional laser therapy for clearing AK and improving skin quality. To compare patient friendliness of the "fractional" therapy with those reported for other field treatment modalities.
MATERIALS & METHODS: Ten patients with Fitzpatrick skin type I to III with multiple AK and extensive sun-damaged skin, received 5-10 sessions with a 4-week interval using a 1550 nm Erbium-Glass Fractionated laser (Sellas, Korea). Four weeks and 24 weeks after the last treatment the clinical results were evaluated by an independent physician.
RESULTS: The mean degree of improvement, in terms of reduction in the number of AK and improvement of skin texture, was 54% on a 4 point PGA scale, and persisted for approximately 6 months. The biggest advantage of fractional laser treatment, besides the eradication of AK and a clear rejuvenation effect, is the absence of "downtime".
CONCLUSION: Fractional non-ablative resurfacing induces significant reduction in the number of AK and improves the skin quality. Also all patients preferred fractional laser therapy above other AK treatment modalities.
Sebastiaan P Prens; Karin de Vries; H A Martino Neumann; Errol P Prens
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Publication Detail:
Type:  Journal Article     Date:  2012-06-12
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  24     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-06-18     Revised Date:  2014-01-29    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-31     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Combined Modality Therapy
Edema / etiology
Erythema / etiology
Keratolytic Agents / administration & dosage*
Keratosis, Actinic / etiology,  therapy*
Laser Therapy / adverse effects,  methods*
Middle Aged
Pain Measurement
Pilot Projects
Skin / radiation effects
Sunlight / adverse effects
Tretinoin / administration & dosage*
Reg. No./Substance:
0/Keratolytic Agents; 5688UTC01R/Tretinoin
Comment In:
J Dermatolog Treat. 2014 Aug;25(4):298   [PMID:  23331072 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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