| Non-vertebrate models to study parasite invasion of the central nervous system. | |
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MedLine Citation:
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PMID: 20832363 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Infections of the central nervous system due to neuroparasites have contributed significantly to morbidity and mortality. In part, this is because of our incomplete understanding of parasite traversal of the blood-brain barrier, a key step in the development of central nervous system infections, and the lack of available drugs that can cross the blood-brain barrier to gain entry into the brain to kill parasites. The novel in vitro, ex vivo, and in vivo models of the blood-brain barrier can offer strategies to elucidate the physical barriers, cellular mechanisms and molecular elements participating from both sides of parasite-host interactions leading to neuropathogenesis. Improving our knowledge of these core processes might elevate the efficiency of therapy of diseases caused by them. |
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Authors:
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Ruqaiyyah Siddiqui; Richard Pleass; Parisa Mortazavi; Naveed Ahmed Khan |
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Publication Detail:
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Type: Journal Article Date: 2010-09-09 |
Journal Detail:
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Title: Trends in parasitology Volume: 27 ISSN: 1471-5007 ISO Abbreviation: Trends Parasitol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966034 Medline TA: Trends Parasitol Country: England |
Other Details:
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Languages: eng Pagination: 5-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK, LE12 5RD, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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