| Non-tuberculous mycobacterial infections in the Scottish Borders: identification, management and treatment outcomes - a retrospective review. | |
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MedLine Citation:
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PMID: 22184566 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Non-tuberculous mycobacteria are opportunist pathogens increasingly recognised as a cause of pulmonary and extrapulmonary disease. Treatment is complicated, prolonged and potentially toxic, and due to a limited evidence base, potentially contentious and idiosyncratic. This is a retrospective review of non-tuberculous mycobacteria cases in the NHS Borders Health Board between 1992 and 2010. We consider incidence, species identified, drug sensitivity testing and treatment outcome with reference to the British and American Thoracic Society guidelines. Thirty-eight cases of non-tuberculous mycobacteria isolates were identified; 84.21% were pulmonary and 42.11% were Mycobacterium avium complex. Incidence rose from 1.92/100,000 in 1993 to 4.43/100,000 in 2010. The British Thoracic Society guidelines were followed in 45.45% of cases. A total of 36.36% were successfully treated with another 36.36% still being treated with antimicrobials. There is a clear need for more research on treatment for this group of 'emerging pathogens' and it remains to be seen if concordance with current guidelines will improve treatment outcomes. |
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Authors:
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A D McCallum; S W Watkin; J F Faccenda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of the Royal College of Physicians of Edinburgh Volume: 41 ISSN: 2042-8189 ISO Abbreviation: J R Coll Physicians Edinb Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101144324 Medline TA: J R Coll Physicians Edinb Country: Scotland |
Other Details:
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Languages: eng Pagination: 294-303 Citation Subset: IM |
Affiliation:
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Borders General Hospital, Melrose, Roxburghshire, TD6 9BS, Scotland, UK. jakki.faccenda@borders.scot.nhs.uk. |
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