Document Detail

Non-toxigenic Corynebacterium diphtheriae biovar gravis: evidence for an invasive clone in a south-eastern Australian community.
MedLine Citation:
PMID:  8569575     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the prevalence and clonality of non-toxigenic Corynebacterium diphtheriae biovar gravis in a community with two cases of endocarditis caused by this organism. SETTING: A Koorie (Aboriginal) community in Gippsland, eastern Victoria, in 1994. METHODS: Nose and throat swabs were collected from 359 community contacts of the cases and cultured for C. diphtheriae. Strains isolated from the contacts were compared by pulsed-field gel electrophoresis (after digestion with Sma1, Not1 and Sfi1) with those from the invasive cases in the same community, another invasive case in Victoria, a cluster of invasive cases in New South Wales (NSW) (1990-1991), and other stored strains isolated from skin ulcers and sore throats. RESULTS: Non-toxigenic strains of C. diphtheriae biovar gravis were isolated from throat swabs of five of the case contacts. Uniform DNA patterns were found for the two community cases, the other Victorian case, nine of ten isolates from NSW, and the five throat isolates from case contacts. CONCLUSION: An invasive clone of C. diphtheriae biovar gravis appears to have been responsible for the three Victorian cases of endocarditis. It was also present among case contacts and responsible for previous invasive cases in NSW. Prophylactic treatment should be considered for clearly defined contacts in all instances where C. diphtheriae is isolated from a normally sterile site, regardless of the toxigenic nature of the strain.
G G Hogg; J E Strachan; L Huayi; S A Beaton; P M Robinson; K Taylor
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  164     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-03-06     Completed Date:  1996-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  72-5     Citation Subset:  IM    
Microbiological Diagnostic Unit, University of Melbourne, VIC.
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MeSH Terms
Arthritis, Infectious / microbiology
Australia / epidemiology
Carrier State / epidemiology*,  microbiology
Chronic Disease
Corynebacterium Infections / epidemiology*,  microbiology*,  prevention & control
Corynebacterium diphtheriae / classification*,  genetics,  isolation & purification
DNA, Bacterial*
Electrophoresis, Gel, Pulsed-Field
Endocarditis, Bacterial / microbiology*
Middle Aged
Nose / microbiology
Oceanic Ancestry Group
Pharynx / microbiology
Skin Ulcer / microbiology
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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