| Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia. | |
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MedLine Citation:
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PMID: 21726656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections. |
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Authors:
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Seth T Walk; Ruchika Jain; Itishree Trivedi; Sylvia Grossman; Duane W Newton; Tennille Thelen; Yibai Hao; J Glenn Songer; Glen P Carter; Dena Lyras; Vincent B Young; David M Aronoff |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-06-25 |
Journal Detail:
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Title: Anaerobe Volume: 17 ISSN: 1095-8274 ISO Abbreviation: Anaerobe Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-29 Completed Date: 2012-01-11 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 9505216 Medline TA: Anaerobe Country: England |
Other Details:
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Languages: eng Pagination: 252-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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The Department of Internal Medicine, University of Michigan Health System, Ann Arbor, 48109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Animals Bacteremia / microbiology* Bacterial Toxins / genetics, metabolism* Cholangitis / microbiology* Clostridium sordellii / metabolism, pathogenicity* Disease Models, Animal Female Humans Mice Mice, Inbred C57BL Peritonitis / microbiology Virulence |
| Grant Support | |
ID/Acronym/Agency:
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HL078727/HL/NHLBI NIH HHS; R01 HD057176-04/HD/NICHD NIH HHS; R01 HD057176-05/HD/NICHD NIH HHS; UL1RR024986/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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