| Non-syndromic thoracic aortic aneurysms and dissections-a genetic review. | |
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MedLine Citation:
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PMID: 23276923 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Thoracic aortic aneurysm and dissections (TAADs) are associated with both high mortality and medical expense. Poor outcomes are preventable by surgical repair; however, identifying individuals at-risk is difficult. Researchers are scanning the human genome to characterize the genetic determinants of TAADs by identifying chromosomal regions, gene mutations, single nucleotide polymorphism (SNP), genomic copy number variants and micro-RNA variants, with the purpose of analyzing the risk of TAADs associated with these predisposing genes. The goal of this review is to develop screening tests to identify individuals at risk for non-syndromic TAADs. This genetic survey has significant clinical implications because high-risk individuals can be closely monitored and can benefit from preventative surgical repair. |
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Authors:
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Pengyu Zhang; Eryong Zhang; Jingxiu Fan; Jun Gu |
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Publication Detail:
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Type: Journal Article Date: 2013-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 18 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 305-11 Citation Subset: IM |
Affiliation:
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Cardiovascular and Thoracic Surgery Department, West China Hospital of Sichuan University, No. 17 Third Section of South Renmin Road, Chengdu, China, 610041. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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