Document Detail


Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects.
MedLine Citation:
PMID:  19162780     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Mechanisms underlying the circadian profile of cardiovascular events (CE) are not totally understood. Whether circadian changes in arterial stiffness (AS) could be related to the circadian profile of CE remains to be investigated. As yet, there is no accepted way to measure circadian profiles or nocturnal-related and/or morning-related changes in cardiovascular variables. The aim of this study was to characterize the circadian pattern and day-night and night-day changes of AS in untreated hypertensive (HG) and healthy subjects (NG), using a recently developed non-symmetrical six-parameter double-logistic model. METHODS: Seven hypertensive and seven normotensive subjects underwent 24 hour ambulatory recordings of blood pressure (BP), heart rate (HR) and aorto-brachial pulse transit time (PTT(AB)) and pulse transit velocity index (PTV(AB)). PTT(AB) and PTV(AB) are inversely and directly related to AS, respectively. The circadian profile and transitional periods (day-night and night-day) were analyzed using a model described by a six-parameter double logistic equation. CONCLUSIONS: The model was adequate to characterize the circadian pattern of AS. We provide the first evidence that AS in humans follows an asymmetric circadian pattern and that this differs between NG and HG. In both NG and HG, AS had a circadian profile, with the highest levels in the night. HG showed larger levels of AS, larger BP variations and rate of change and minor changes in AS during transitional periods.
Authors:
D Bia; R Armentano; F Pessana; Y Zócalo; S Lluberas; A P Avolio
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference     Volume:  2008     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2008  
Date Detail:
Created Date:  2009-02-16     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  809-12     Citation Subset:  IM    
Affiliation:
Physiology Department, School of Medicine, Republic University, General Flores 2125, PC: 11800, Montevideo, Uruguay. dbia@fmed.edu.uy
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MeSH Terms
Descriptor/Qualifier:
Adult
Aorta / physiopathology*
Brachial Artery / physiology*
Circadian Rhythm*
Computer Simulation
Elastic Modulus
Female
Humans
Hypertension / diagnosis,  physiopathology*
Logistic Models
Male
Models, Cardiovascular*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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