Document Detail

Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy: an independent marker of sudden death risk in young patients.
MedLine Citation:
PMID:  12957435     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to examine the characteristics of non-sustained ventricular tachycardia (NSVT) episodes during Holter monitoring and to determine their relationship to age and prognosis. BACKGROUND: It has been suggested that NSVT is only of prognostic importance in patients with hypertrophic cardiomyopathy (HCM) when repetitive, prolonged, or associated with symptoms. METHODS: We studied 531 patients with HCM (323 male, 39 +/- 15 years). All underwent ambulatory electrocardiogram monitoring (41 +/- 11 h). RESULTS: A total of 104 patients (19.6%) had NSVT. The proportion of patients with NSVT increased with age (p = 0.008). Maximum left ventricular wall thickness and left atrial size were greater in patients with NSVT. Mean follow-up was 70 +/- 40 months. Sixty-eight patients died, 32 from sudden cardiac death (SCD). Twenty-one patients received an implantable cardioverter defibrillator (ICD). There were four appropriate ICD discharges. In patients < or =30 years (but not >30), five-year freedom from sudden death was lower in those with NSVT (77.6% [95% confidence interval (CI): 59.8 to 95.4] vs. 94.1% [95% CI: 90.2 to 98.0]; p = 0.003). There was no relation between the duration, frequency, or rate of NSVT runs and prognosis at any age. The odds ratio of sudden death in patients < or =30 years of age with NSVT was 4.35 (95% CI: 1.54 to 12.28; p = 0.006) compared with 2.16 (95% CI: 0.82 to 5.69; p = 0.1) in patients >30 years of age. CONCLUSIONS: Non-sustained ventricular tachycardia is associated with a substantial increase in sudden death risk in young patients with HCM. A relation between the frequency, duration, and rate of NSVT episodes could not be demonstrated.
Lorenzo Monserrat; Perry M Elliott; Juan R Gimeno; Sanjay Sharma; Manuel Penas-Lado; William J McKenna
Related Documents :
18036455 - Noncontact mapping and radiofrequency catheter ablation of fast and hemodynamically uns...
3655145 - Signal averaging of the surface qrs complex predicts inducibility of ventricular tachyc...
2423985 - Amiodarone: value of programmed electrical stimulation and holter monitoring.
9080025 - Hypertrophic cardiomyopathy: value of atrial programmed electrical stimulation in patie...
9509565 - Oxidative stress and enzyme activity in ambulatory renal patients undergoing continuous...
21644045 - A comparative analysis of serological parameters and oxidative stress in osteoarthritis...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  42     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-05     Completed Date:  2003-10-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  873-9     Citation Subset:  AIM; IM    
Service of Cardiology, Juan Canalejo Hospital, A Coruña, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Distribution
Biological Markers
Cardiomyopathy, Hypertrophic / complications*
Death, Sudden, Cardiac / epidemiology,  etiology*
Electrocardiography, Ambulatory
Exercise Test
Follow-Up Studies
Heart Rate
Hypertrophy, Left Ventricular / etiology
London / epidemiology
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Proportional Hazards Models
Risk Assessment / methods,  standards
Risk Factors
Survival Analysis
Tachycardia, Ventricular / diagnosis*,  etiology*
Reg. No./Substance:
0/Biological Markers
Comment In:
J Am Coll Cardiol. 2003 Sep 3;42(5):880-1   [PMID:  12957436 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart...
Next Document:  Clinical course of hypertrophic cardiomyopathy with survival to advanced age.