| Non-sustained ventricular tachycardia as a predictor of sudden cardiac death in patients with left ventricular dysfunction: a meta-analysis. | |
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MedLine Citation:
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PMID: 18692437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Identifying patients at risk of sudden cardiac death (SCD) remains a challenge. AIM: To evaluate the performance of non-sustained ventricular tachycardia (NSVT) from 24 hour ambulatory electrocardiography as a predictor of SCD in patients with heart failure or non-ischaemic dilated cardiomyopathy with left ventricular systolic dysfunction (LVSD). METHODS AND RESULTS: Study search and selection were performed by independent reviewers using a validated strategy. Eleven prognostic studies with >100 patients with good quality data and multivariate analysis of predictors of SCD were included. Publication bias was evaluated by funnel plot with Kendall's tau b test. A summary ROC (sROC) curve was built to evaluate predictive performance of NSVT. There was threshold effect (Spearman's correlation between sensitivity and specificity=-0.818, p<0.01) which indicates that combining sensitivity and specificity was not appropriate. The area of 0.68+/-0.02 under the sROC curve indicates a statistically significant contribution of NSVT in the prediction of SCD. The true negative rate varied from 89 to 97%. Multivariate analysis and meta-regression suggested that the contribution of NSVT to risk stratification is independent of ejection fraction. CONCLUSIONS: Absence of NSVT indicated a low probability of SCD in patients with LVSD. A risk score including NSVT should be evaluated in prospective studies. |
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Authors:
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Marcos R de Sousa; Carlos A Morillo; Fábio T Rabelo; Antônio M Nogueira Filho; Antonio L P Ribeiro |
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Publication Detail:
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Type: Journal Article; Meta-Analysis Date: 2008-08-09 |
Journal Detail:
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Title: European journal of heart failure Volume: 10 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-02-11 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1007-14 Citation Subset: IM |
Affiliation:
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Post-Graduate Program in Internal Medicine, Universidade Federal de Minas Gerais, Brazil. sousa.mr@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathy, Dilated
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physiopathology Death, Sudden, Cardiac / etiology*, pathology Heart Failure / physiopathology Humans Multivariate Analysis Predictive Value of Tests Prognosis ROC Curve Risk Factors Sensitivity and Specificity Tachycardia, Ventricular / complications*, physiopathology Time Factors Ventricular Dysfunction, Left / complications*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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