| Non-surgical management of stress urinary incontinence: ambulatory treatments for leakage associated with stress (ATLAS) trial. | |
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MedLine Citation:
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PMID: 17327249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. PURPOSE: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. METHODS: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient Global Impression of Improvement (PGI-I), the Stress Incontinence Scale of the Pelvic Floor Distress Inventory (PFDI), seven-day bladder diaries, Pelvic Floor Impact Questionnaire (PFIQ), Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12), Patient Satisfaction Questionnaire (PSQ) and the Medical Outcomes Study Short Form Health Survey (SF-36). LIMITATIONS: The study design reduces most common biases, but some degree of selection bias may remain. CONCLUSION: This trial will provide useful information to help counsel women with stress and mixed incontinence about the relative efficacy and satisfaction with pessary, behavioral therapy and both treatments combined. |
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Authors:
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Holly E Richter; Kathryn L Burgio; Patricia S Goode; Diane Borello-France; Catherine S Bradley; Linda Brubaker; Victoria L Handa; Paul M Fine; Anthony G Visco; Halina M Zyczynski; John T Wei; Anne M Weber; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Clinical trials (London, England) Volume: 4 ISSN: 1740-7745 ISO Abbreviation: Clin Trials Publication Date: 2007 |
Date Detail:
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Created Date: 2007-02-28 Completed Date: 2007-06-14 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101197451 Medline TA: Clin Trials Country: England |
Other Details:
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Languages: eng Pagination: 92-101 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Division of Women's Pelvic Medicine and Reconstructive Surgery, University of Alabama at Birmingham, Bermingham, Alabama 35249-7333, USA. hrichter@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ambulatory Care* Female Health Care Surveys Humans Patient Satisfaction Quality of Life Questionnaires Research Design Sample Size Selection Bias Treatment Outcome Urinary Incontinence, Stress / therapy* |
| Grant Support | |
ID/Acronym/Agency:
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K24 DK068389/DK/NIDDK NIH HHS; U01 HD41249/HD/NICHD NIH HHS; U10 HD41248/HD/NICHD NIH HHS; U10 HD41250/HD/NICHD NIH HHS; U10 HD41261/HD/NICHD NIH HHS; U10 HD41263/HD/NICHD NIH HHS; U10 HD41267/HD/NICHD NIH HHS; U10 HD41268/HD/NICHD NIH HHS; U10 HD41269/HD/NICHD NIH HHS |
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