Document Detail

Non-stress-related factors associated with maternal corticotrophin-releasing hormone (CRH) concentration.
MedLine Citation:
PMID:  20618729     Owner:  NLM     Status:  MEDLINE    
During pregnancy, most maternal corticotrophin-releasing hormone (CRH) is secreted by the placenta, not the hypothalamus. Second trimester maternal CRH concentration is robustly associated with the subsequent risk of preterm birth, and it is often assumed that physiological and/or psychological stress stimulates placental CRH release. Evidence supporting the latter assumption is weak, however, and other factors affecting maternal CRH have received little attention from investigators. We carried out a case-control study nested within a large, multicentre prospective cohort of pregnant women to examine potential 'upstream' factors associated with maternal CRH concentration measured at 24-26 weeks of gestation. The predictors studied included maternal age, parity, birthplace (as a proxy for ethnic origin), pre-pregnancy body mass index, height, smoking, bacterial vaginosis and vaginal fetal fibronectin (FFN) concentration. Women with high (above the median) plasma CRH concentration were significantly less likely to have been born in Sub-Saharan Africa or the Caribbean, less likely to be overweight or obese, and more likely to be smokers. Associations with maternal birthplace and BMI persisted in logistic regression analyses controlling for potential confounding variables and when restricted to term controls. A strong (but imprecise and statistically non-significant) association was also observed with high vaginal FFN concentration. Further studies are indicated both in animal models and human populations to better understand the biochemical and physiological pathways to CRH secretion and their aetiological role, if any, in preterm birth.
Michael S Kramer; John Lydon; Louise Séguin; Lise Goulet; Susan R Kahn; Helen McNamara; Jacques Genest; Shakti Sharma; Michael J Meaney; Michael Libman; Mourad Dahhou; Robert W Platt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  24     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  390-7     Citation Subset:  IM    
Departments of Pediatrics, McGill University Faculty of Medicine, and Département de médecine sociale et préventive, Faculté de médecine de l'Université de Montréal, Montréal, Québec, Canada.
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MeSH Terms
Body Height
Body Mass Index
Case-Control Studies
Corticotropin-Releasing Hormone / blood*
Ethnic Groups
Fibronectins / analysis
Maternal Age
Pregnancy Trimester, Second / blood*
Risk Factors
Vaginosis, Bacterial / epidemiology
Young Adult
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/FFN protein, human; 0/Fibronectins; 9015-71-8/Corticotropin-Releasing Hormone

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