| Non-steroidal pregnancy-terminating agents: design, synthesis and structure-activity relationships of 2-aryl-1,2,4-triazolo[1,5-a]pyridine. | |
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MedLine Citation:
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PMID: 12161145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The syntheses and the pregnancy-terminating activity relationships of compounds -n are reported. Compounds 5b and are found to be more potent than DL-111-a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration. |
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Authors:
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Tao Liu; Yongzhou Hu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 12 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-08-05 Completed Date: 2003-07-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 2411-3 Citation Subset: IM |
Affiliation:
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Zhejiang University, Department of Medicinal Chemistry, College of Pharmacy, Hangzhou 310031, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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chemical synthesis*,
pharmacology Animals Drug Design Embryo Implantation / drug effects Embryo, Mammalian / drug effects Luteolysis / drug effects Luteolytic Agents / chemical synthesis, pharmacology Mice Pyridines / chemical synthesis, pharmacology Structure-Activity Relationship Triazoles / chemical synthesis, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Luteolytic Agents; 0/Pyridines; 0/Triazoles; 69095-83-6/3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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