Document Detail

Non-steroidal anti-inflammatory drugs, hiatus hernia, and Helicobacter pylori, in patients with oesophageal ulceration.
MedLine Citation:
PMID:  2379044     Owner:  NLM     Status:  MEDLINE    
The frequency of oesophageal ulceration in 55 patients undergoing endoscopy for dyspeptic symptoms and who had recently used NSAIDs was studied, and compared with 86 patients seen in the same clinic who had not recently used these drugs. Oesophageal ulceration was significantly more common in those who had used NSAIDs (P = 0.012), and also showed a highly significant association with the presence of a hiatus hernia (P less than 0.001). No association was found between the presence of gastric Helicobacter pylori and either oesophageal ulceration or histological oesophagitis. Patients receiving NSAIDs, especially those with a hiatus hernia, are at risk of oesophageal ulceration and presumably subsequent stricture formation. This should be borne in mind when prescribing these agents.
T M Shallcross; J I Wyatt; B J Rathbone; R V Heatley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  29     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-13     Completed Date:  1990-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  288-90     Citation Subset:  AIM; IM    
Department of Medicine, St James's Hospital, Leeds.
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Campylobacter / isolation & purification
Campylobacter Infections / complications*,  pathology
Esophageal Diseases / chemically induced,  complications*,  pathology
Gastric Mucosa / microbiology,  pathology
Hernia, Diaphragmatic / complications*
Hernia, Hiatal / complications*,  pathology
Middle Aged
Ulcer / chemically induced,  complications*,  pathology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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