Document Detail


Non-steroidal anti-inflammatory drugs for lower urinary tract symptoms in benign prostatic hyperplasia: systematic review and meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  23356748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in men with benign prostatic hyperplasia (BPH) using systematic review and meta-analysis of clinical trials.
SUBJECTS: Men treated with NSAIDs in comparison with placebo or other BPH medications.
METHODS: All aspects of the Preferred Reporting for Systematic Reviews and Meta-Analyses (PRISMA) statement were followed. Trials were eligible for inclusion provided they (i) randomized men with BPH to receive NSAIDs in comparison with placebo or other BPH medications, and (ii) included clinical outcomes such as urological symptom scales, symptoms or urodynamic measurements. Data analysis was performed using REVIEW MANAGER Version 5.0 software. Study weight was calculated by the inverse variances of the study effect estimates.
RESULTS: In all, 183 men from three randomized, placebo-controlled trials (lasting 4-24 weeks) were assessed. NSAIDs improved urinary symptom scores and flow measures. The weighted mean difference for the International Prostate Symptom Score (IPSS) was -2.89 IPSS points (95% CI -3.84 to -1.95, P < 0.001, n = 3 studies). The weighted mean difference for peak urine flow was 0.89 mL/s (95% CI 0.21-1.58, P = 0.01, n = 3 studies) and for reported adverse effects was 1.51 (95% CI 0.66-3.43, P = 0.32, n = 3 studies,). All patients assigned to NSAIDs continued the treatment. There were no serious adverse effects and there were no withdrawals or losses to follow-up.
CONCLUSION: The evidence suggests that NSAIDs improve urinary symptoms and flow measures. Their long-term effectiveness, safety and ability to prevent BPH complications are not known.
Authors:
Arman Kahokehr; Ryash Vather; Anthony Nixon; Andrew G Hill
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  BJU international     Volume:  111     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-03-20     Revised Date:  2013-11-19    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  304-11     Citation Subset:  IM    
Copyright Information:
© 2013 BJU International.
Affiliation:
Department of Urology, Northland District Health Board, Whangarei Hospital, Whangarei, New Zealand. arman.kahokehr@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Humans
Male
Middle Aged
Prostatic Hyperplasia / complications*,  physiopathology
Prostatism / drug therapy*,  physiopathology
Randomized Controlled Trials as Topic
Urination / physiology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal
Comments/Corrections
Comment In:
J Urol. 2013 Nov;190(5):1819   [PMID:  24120798 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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