| Non-steroidal anti-inflammatory drugs and perforated diverticular disease: a case-control study. | |
| | |
MedLine Citation:
|
PMID: 11995772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Non-steroidal anti-inflammatory drugs (NSAIDs) have a wide range of side-effects in the gastrointestinal tract and the large intestine. This study examines the hypothesis that the use of NSAIDs is associated with colonic perforation in diverticular disease. Histological evidence was used to confirm perforation. A retrospective review of case records and pathology reports identified 20 patients admitted over 3 consecutive years. A total of 125 age- and sex-matched patients diagnosed with diverticular disease not complicated by perforation formed the control group. The incidences of NSAID use in the two groups were compared. A second control group consisted of 600 age- and sex-matched randomly selected patients with no known diverticular disease admitted as emergencies in the same period. Of the 20 patients with perforation, 9 were taking NSAIDs for 4 weeks or longer, compared with 19 (15%) of the 125 patients who did not have perforation (relative risk 2.961, 95% confidence interval 1.507-5.348, P < 0.01). 19% of all patients with diverticular disease were taking NSAIDs compared with 10% of the second control group (relative risk 1.869, 95% confidence interval 1.237-2.781, P < 0.01). The findings indicate a strong association between the use of NSAIDs and the perforation of colonic diverticula. The majority of the indications for the use of NSAIDs were cardiovascular and musculoskeletal conditions. Prescribing NSAIDs to patients with diverticular disease carries an increased risk of colonic perforation. |
| | |
Authors:
|
H Goh; R Bourne |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Annals of the Royal College of Surgeons of England Volume: 84 ISSN: 0035-8843 ISO Abbreviation: Ann R Coll Surg Engl Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-05-08 Completed Date: 2002-05-31 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7506860 Medline TA: Ann R Coll Surg Engl Country: England |
Other Details:
|
Languages: eng Pagination: 93-6 Citation Subset: IM |
Affiliation:
|
Department of General Surgery, North Devon District Hospital, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anti-Inflammatory Agents, Non-Steroidal / adverse effects* Case-Control Studies Diverticulum, Colon / chemically induced*, surgery Female Humans Intestinal Perforation / chemically induced*, surgery Laparotomy / methods Male Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents, Non-Steroidal |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term follow-up of endoscopic stapled diverticulotomy.
Next Document: Intraspinal oxidised cellulose (Surgicel) causing delayed paraplegia after thoracotomy--a report of ...