Document Detail


Non-steroidal anti-inflammatory drugs inhibit telomerase activity in head and neck squamous carcinoma cell lines.
MedLine Citation:
PMID:  11774390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Antiproliferative effects in neoplastic cells of different origin have been attributed to non-steroidal anti-inflammatory Drugs (NSAIDs) during the past few decades. METHODS: We tested the influence of NSAIDs and hydrocortisone on cell lines derived from head and neck squamous cell cancer (HNSCC) and on normal oral mucosal keratinocytes. Cell numbers were assayed by cell counting, proliferation, telomerase activity with a colorimetric assay, and cell cycle distribution by flow cytometry. RESULTS: In the neoplastic cell lines indomethacin and ibuprofen caused a dose-dependent reduction of cell numbers and telomerase activity without altering cell viability and increased the percentage of cells in G0/G1 phase. In normal oral mucosal keratinocytes, only minor effects could be detected in response to NSAIDs and hydrocortisone. CONCLUSION: These results demonstrate that NSAIDs have activity against HNSCC cells in vitro and may have clinical applications in combination with other therapeutic regimens.
Authors:
D Thurnher; M Bakroeva; M Formanek; B Knerer; J Kornfehl
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Head & neck     Volume:  23     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-04     Completed Date:  2002-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1049-55     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Inc.
Affiliation:
Department of Otorhinolaryngology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. dietmar.thurnher@univie.ac.at
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Antineoplastic Agents / pharmacology
Carcinoma, Squamous Cell / drug therapy,  enzymology,  pathology*
Cell Cycle / drug effects*
Cell Division / drug effects
Head and Neck Neoplasms / drug therapy,  enzymology,  pathology*
Humans
Hydrocortisone / pharmacology
Ibuprofen / pharmacology
Indomethacin / pharmacology
Keratinocytes
Telomerase / antagonists & inhibitors*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antineoplastic Agents; 15687-27-1/Ibuprofen; 50-23-7/Hydrocortisone; 53-86-1/Indomethacin; EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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