| Non-steady state monitoring by respiratory gas exchange. | |
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MedLine Citation:
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PMID: 12580218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Traditionally, the study of CO2 and O2 kinetics in the body has been mostly confined to equilibrium conditions. However, the peri-anesthesia period and the critical care arena often involve conditions of non-steady state. The detection and explanation of CO2 kinetics during non-steady state pathophysiology have required the development of new methodologies, including the CO2 expirogram, average alveolar expired PCO2, and CO2 volume exhaled per breath. Several clinically relevant examples of non-steady state CO2 kinetics perturbations are examined, including abrupt decrease in cardiac output, application of positive end-expiratory pressure during mechanical ventilation, and occurrence of pulmonary embolism. The lesser known area of non-steady state O2 kinetics is introduced, including the measurement of pulmonary O2 uptake per breath. Future directions include the study of the respiratory quotient per breath, where the anaerobic threshold during anesthesia is identified by increasing respiratory quotient. |
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Authors:
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P H Breen; S A Isserles; U Z Taitelman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of clinical monitoring and computing Volume: 16 ISSN: 1387-1307 ISO Abbreviation: J Clin Monit Comput Publication Date: 2000 |
Date Detail:
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Created Date: 2003-02-12 Completed Date: 2003-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9806357 Medline TA: J Clin Monit Comput Country: Netherlands |
Other Details:
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Languages: eng Pagination: 351-60 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of California-Irvine, UCI Medical Center, Orange, California 92868, USA. pbreen@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Dioxide
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analysis,
pharmacokinetics* Cardiac Output Humans Kinetics Monitoring, Physiologic Oxygen / analysis, pharmacokinetics* Pulmonary Embolism / diagnosis Pulmonary Gas Exchange* Respiration, Artificial Respiratory Function Tests |
| Grant Support | |
ID/Acronym/Agency:
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HL-42637/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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