Document Detail

Non-steady state monitoring by respiratory gas exchange.
MedLine Citation:
PMID:  12580218     Owner:  NLM     Status:  MEDLINE    
Traditionally, the study of CO2 and O2 kinetics in the body has been mostly confined to equilibrium conditions. However, the peri-anesthesia period and the critical care arena often involve conditions of non-steady state. The detection and explanation of CO2 kinetics during non-steady state pathophysiology have required the development of new methodologies, including the CO2 expirogram, average alveolar expired PCO2, and CO2 volume exhaled per breath. Several clinically relevant examples of non-steady state CO2 kinetics perturbations are examined, including abrupt decrease in cardiac output, application of positive end-expiratory pressure during mechanical ventilation, and occurrence of pulmonary embolism. The lesser known area of non-steady state O2 kinetics is introduced, including the measurement of pulmonary O2 uptake per breath. Future directions include the study of the respiratory quotient per breath, where the anaerobic threshold during anesthesia is identified by increasing respiratory quotient.
P H Breen; S A Isserles; U Z Taitelman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical monitoring and computing     Volume:  16     ISSN:  1387-1307     ISO Abbreviation:  J Clin Monit Comput     Publication Date:  2000  
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9806357     Medline TA:  J Clin Monit Comput     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  351-60     Citation Subset:  IM    
Department of Anesthesiology, University of California-Irvine, UCI Medical Center, Orange, California 92868, USA.
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MeSH Terms
Carbon Dioxide / analysis,  pharmacokinetics*
Cardiac Output
Monitoring, Physiologic
Oxygen / analysis,  pharmacokinetics*
Pulmonary Embolism / diagnosis
Pulmonary Gas Exchange*
Respiration, Artificial
Respiratory Function Tests
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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