| Non-specific bronchial hyperresponsiveness is a risk factor for steroid insensitivity in nasal polyposis. | |
| | |
MedLine Citation:
|
PMID: 15143747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Management of nasal polyposis should be primarily medical. Resorting to intranasal ethmoidectomy should not be envisaged before a trial of dual steroid therapy. Nevertheless, no risk factor for steroid insensitivity in patients with nasal polyposis is actually defined. The aim of this study is to evaluate whether the presence of asthma and/or non-specific bronchial hyperresponsiveness (BHR) can be considered a risk factor for steroid insensitivity. MATERIAL AND METHODS: This study focused on the evaluation of a dual modality, topical and systemic, over a follow-up period of 3 years. A total of 55 subjects with and 45 subjects without BHR were treated according to a standardized therapeutic protocol combining short-term oral administration of prednisolone and a daily intranasal spray of beclomethasone. RESULTS: Over the follow-up period of 3 years, this dual modality proved to be successful in 93.4% of subjects without BHR and without aspirin idiosyncrasy, in 82.2% of subjects with BHR and without aspirin idiosyncrasy and in 60% of subjects with BHR and aspirin idiosyncrasy. The percentage of patients who underwent surgery after the failure of medical treatment was significantly larger in patients with than without BHR (p < 0.05) and in patients with than without aspirin idiosyncrasy (p < 0.02). CONCLUSION: The presence of BHR and/or aspirin idiosyncrasy can be considered a major risk factor for steroid insensitivity in patients with nasal polyposis. |
| | |
Authors:
|
Pierre Bonfils; Paul Avan |
Related Documents
:
|
18317527 - Angioedema: clinical and etiological aspects. 8454797 - Hyposmia in allergic rhinitis. 10459117 - Oral lesions and symptoms related to metals used in dental restorations: a clinical, al... 3400897 - Ige values in the allergic and healthy israeli population. 17664917 - Oral health status in patients with moderate-severe and terminal renal failure. 14685707 - Statin therapy in patients with coronary artery disease improves the impaired endotheli... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta oto-laryngologica Volume: 124 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 2004 Apr |
Date Detail:
|
Created Date: 2004-05-14 Completed Date: 2005-01-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: Norway |
Other Details:
|
Languages: eng Pagination: 290-6 Citation Subset: IM |
Affiliation:
|
ENT Research Laboratory and Department of Otolaryngology, Head and Neck Surgery I, European Hospital Georges Pompidou, Faculty Necker-Enfants Malades, University René Descartes, Paris, France. pierre.bonfils@egp.ap-hop-paris.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Aerosols Anti-Asthmatic Agents / therapeutic use Anti-Inflammatory Agents, Non-Steroidal / adverse effects Antineoplastic Agents, Hormonal / therapeutic use Aspirin / adverse effects Asthma / complications*, drug therapy, physiopathology Beclomethasone / administration & dosage, therapeutic use* Bronchial Hyperreactivity / complications*, drug therapy Bronchial Provocation Tests Drug Hypersensitivity / complications Drug Resistance Ethmoid Sinus / radiography, surgery Female Follow-Up Studies Glucocorticoids / administration & dosage, therapeutic use* Humans Irrigation Male Middle Aged Nasal Polyps / complications, drug therapy* Prednisolone / administration & dosage, therapeutic use* Risk Factors Tablets Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Aerosols; 0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antineoplastic Agents, Hormonal; 0/Glucocorticoids; 0/Tablets; 4419-39-0/Beclomethasone; 50-24-8/Prednisolone; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors affecting the herd level of antibodies against Mycobacterium avium subspecies paratuberculos...
Next Document: The Universities of the Renaissance and Reformation.