| Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials. | |
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MedLine Citation:
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PMID: 19939654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Studies evaluating the effect of legume consumption on cholesterol have focused on soybeans, however non-soy legumes, such as a variety of beans, peas, and some seeds, are commonly consumed in Western countries. We conducted a meta-analysis of randomized controlled trials evaluating the effects of non-soy legume consumption on blood lipids. METHODS AND RESULTS: Studies were retrieved by searching MEDLINE (from January 1966 through July 2009), EMBASE (from January 1980 to July 2009), and the Cochrane Collaboration's Central Register of Controlled Clinical Trials using the following terms as medical subject headings and keywords: fabaceae not soybeans not isoflavones and diet or dietary fiber and cholesterol or hypercholesterolemia or triglycerides or cardiovascular diseases. Bibliographies of all retrieved articles were also searched. From 140 relevant reports, 10 randomized clinical trials were selected which compared a non-soy legume diet to control, had a minimum duration of 3 weeks, and reported blood lipid changes during intervention and control. Data on sample size, participant characteristics, study design, intervention methods, duration, and treatment results were independently abstracted by 2 investigators using a standardized protocol. Data from 10 trials representing 268 participants were examined using a random-effects model. Pooled mean net change in total cholesterol for those treated with a legume diet compared to control was -11.8 mg/dL (95% confidence interval [CI], -16.1 to -7.5); mean net change in low-density lipoprotein cholesterol was -8.0mg/dL (95% CI, -11.4 to -4.6). CONCLUSION: These results indicate that a diet rich in legumes other than soy decreases total and LDL cholesterol. |
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Authors:
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L A Bazzano; A M Thompson; M T Tees; C H Nguyen; D M Winham |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural Date: 2009-11-25 |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 21 ISSN: 1590-3729 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-05-19 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 94-103 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. lbazzano@tulane.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cardiovascular Diseases / diet therapy Cholesterol, HDL / blood* Cholesterol, LDL / blood* Confidence Intervals Diet Fabaceae / chemistry* Female Humans Hypercholesterolemia / diet therapy Isoflavones / pharmacology Linear Models Male Middle Aged Randomized Controlled Trials as Topic Triglycerides / blood Vegetable Proteins / administration & dosage* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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2P20RR017659-06/RR/NCRR NIH HHS; P20 RR017659-077420/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Isoflavones; 0/Triglycerides; 0/Vegetable Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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