Document Detail

Non-smoking and non-drinking patients with head and neck squamous cell carcinoma: a distinct population.
MedLine Citation:
PMID:  17305629     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To recognize specific clinicopathological characteristics of non-smoking and non-drinking (NSND) head and neck squamous cell carcinoma (HNSCC) patients. This can increase our knowledge regarding a potentially different carcinogenesis in these patients. STUDY DESIGN/METHODS: Retrospective analysis of data for 195 NSND patients with HNSCC and comparison with data for patients with HNSCC obtained from the Netherlands Cancer Registry. RESULTS: Compared with all HNSCC patients in the Netherlands, our NSND patients with HNSCC were typically female (n = 142; 73%vs 26%), old at disease presentation (mean 73 years vs 64 years), and had tumors mainly of the oral cavity (n = 130; 66%vs 25%). Most tumors were stage I (n = 67; 34%) and stage IVA (n = 59; 30%). The incidence of second primary tumors (SPTs) was high (n = 32; 16%), mainly occurring in the oral cavity (n = 26; 13%). DISCUSSION/CONCLUSION: Our study confirms that NSND HNSCC patients have different clinicopathological characteristics from those of the overall HNSCC population; however, the frequency of SPTs is as high in NSND patients as in patients who smoke and drink alcohol. More research, and particularly molecular data are needed to obtain a better understanding of head and neck cancer in NSND patients.
F Farshadpour; G J Hordijk; R Koole; P J Slootweg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Oral diseases     Volume:  13     ISSN:  1354-523X     ISO Abbreviation:  Oral Dis     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  D    
Department of Otolaryngology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
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MeSH Terms
Age Factors
Alcohol Drinking
Carcinoma, Squamous Cell / epidemiology*
Head and Neck Neoplasms / epidemiology*
Laryngeal Neoplasms / epidemiology
Lymphatic Metastasis
Middle Aged
Mouth Neoplasms / epidemiology
Neoplasm Staging
Neoplasms, Second Primary / epidemiology
Netherlands / epidemiology
Retrospective Studies
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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