| Non-smoking and non-drinking patients with head and neck squamous cell carcinoma: a distinct population. | |
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MedLine Citation:
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PMID: 17305629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To recognize specific clinicopathological characteristics of non-smoking and non-drinking (NSND) head and neck squamous cell carcinoma (HNSCC) patients. This can increase our knowledge regarding a potentially different carcinogenesis in these patients. STUDY DESIGN/METHODS: Retrospective analysis of data for 195 NSND patients with HNSCC and comparison with data for patients with HNSCC obtained from the Netherlands Cancer Registry. RESULTS: Compared with all HNSCC patients in the Netherlands, our NSND patients with HNSCC were typically female (n = 142; 73%vs 26%), old at disease presentation (mean 73 years vs 64 years), and had tumors mainly of the oral cavity (n = 130; 66%vs 25%). Most tumors were stage I (n = 67; 34%) and stage IVA (n = 59; 30%). The incidence of second primary tumors (SPTs) was high (n = 32; 16%), mainly occurring in the oral cavity (n = 26; 13%). DISCUSSION/CONCLUSION: Our study confirms that NSND HNSCC patients have different clinicopathological characteristics from those of the overall HNSCC population; however, the frequency of SPTs is as high in NSND patients as in patients who smoke and drink alcohol. More research, and particularly molecular data are needed to obtain a better understanding of head and neck cancer in NSND patients. |
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Authors:
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F Farshadpour; G J Hordijk; R Koole; P J Slootweg |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Oral diseases Volume: 13 ISSN: 1354-523X ISO Abbreviation: Oral Dis Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-19 Completed Date: 2007-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 239-43 Citation Subset: D |
Affiliation:
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Department of Otolaryngology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. F.Farshadpour@azu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Alcohol Drinking Carcinoma, Squamous Cell / epidemiology* Female Head and Neck Neoplasms / epidemiology* Humans Incidence Laryngeal Neoplasms / epidemiology Lymphatic Metastasis Male Middle Aged Mouth Neoplasms / epidemiology Neoplasm Staging Neoplasms, Second Primary / epidemiology Netherlands / epidemiology Registries Retrospective Studies Sex Factors Smoking |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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