| Non-small cell lung carcinoma of the superior sulcus: The evolution of treatment outcomes with multimodality treatment at a single institution. | |
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MedLine Citation:
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PMID: 20191604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We evaluated the efficacy of the multimodality approach in treating superior sulcus non-small cell lung carcinoma (SS NSCLC). METHODS: We retrospectively analyzed the records of 57 patients with SS NSCLC who were treated at our institution between 1982 and 2007. RESULTS: During the study period, 3- and 5-year survival increased significantly from 42.6% and 42.6% in the first half of the study period (1982-1994) to 72.7% and 65.4% in the second half (1995-2007), respectively. Methods of clinical staging were unchanged between the two time periods, although the ratio of adenocarcinoma was increased, and multimodality treatment, particularly concurrent chemoradiotherapy followed by surgical resection, was used more frequently in the second half of the study period. The 5-year survival of patients who received preoperative chemoradiotherapy followed by surgery (n = 27) was better than that of those who received other treatment regimen with surgery (n = 22, 64.6% vs. 49.6%; P = 0.044). Five-year survival in patients with complete resection after chemoradiotherapy was 70.4%. Thirteen patients (48%) achieved a pathologic complete response or minimal microscopic disease. CONCLUSIONS: Multimodality treatment with concurrent chemoradiotherapy followed by surgery appears to contribute to improved outcomes over time in patients with SS NSCLC. |
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Authors:
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Tetsuzo Tagawa; Atsushi Osoegawa; Koji Yamazaki; Tatsuro Okamoto; Takuro Kometani; Hiroshi Wataya; Takashi Seto; Seiichi Fukuyama; Fumihiko Hirai; Kenji Sugio; Yukito Ichinose |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of surgical oncology Volume: 101 ISSN: 1096-9098 ISO Abbreviation: J Surg Oncol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 495-9 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Thoracic Oncology, National Kyushu Cancer Center, Minami-ku, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Combined Modality Therapy Female Humans Lung Neoplasms / drug therapy, mortality, radiotherapy, surgery, therapy* Male Middle Aged Small Cell Lung Carcinoma / drug therapy, mortality, radiotherapy, surgery, therapy* Survival Rate Treatment Outcome |
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