| Non-small cell lung cancer staging: efficacy comparison of integrated PET/CT versus 3.0-T whole-body MR imaging. | |
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MedLine Citation:
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PMID: 18552311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare prospectively the diagnostic efficacies of integrated positron emission tomography (PET)/computed tomography (CT) and 3.0-T whole-body magnetic resonance (MR) imaging for determining TNM stages in non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained. The study included 165 patients (125 men, 40 women; mean age, 61 years) with NSCLC proved at pathologic examination who underwent both unenhanced PET/CT and whole-body MR imaging. Pathologic findings for T (n = 123) and N (n = 150) staging and pathologic or follow-up imaging findings (n = 154) for M staging were reference standards. The efficacies of PET/CT and whole-body MR imaging for lung cancer staging were compared by using the McNemar test. RESULTS: Primary tumors (n = 123 patients) were correctly staged in 101 (82%) patients at PET/CT and in 106 (86%) patients at whole-body MR imaging (P = .263). N stages (n = 150 patients) were correctly determined in 105 (70%) patients at PET/CT and in 102 (68%) patients at whole-body MR imaging (P = .880). Thirty-one (20%) of 154 patients had metastatic lesions. Accuracy for detecting metastases was 86% (133 of 154 patients) at PET/CT, and that at whole-body MR imaging was 86% (132 of 154 patients) (P > .99). Although the differences were not statistically significant, whole-body MR imaging was more useful for detecting brain and hepatic metastases, whereas PET/CT was more useful for detecting lymph node and soft-tissue metastases. CONCLUSION: Both PET/CT and 3.0-T whole-body MR imaging appear to provide acceptable accuracy and comparable efficacy for NSCLC staging, but for M-stage determination, each modality has its own advantages. |
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Authors:
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Chin A Yi; Kyung Min Shin; Kyung Soo Lee; Byung-Tae Kim; Hojoong Kim; O Jung Kwon; Joon Young Choi; Myung Jin Chung |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-13 |
Journal Detail:
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Title: Radiology Volume: 248 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 632-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology and Center for Imaging Science, Sungkyunkwan University School of Medicine, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Non-Small-Cell Lung
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pathology* Contrast Media Female Fluorodeoxyglucose F18 / diagnostic use Gadolinium DTPA / diagnostic use Humans Image Processing, Computer-Assisted Lung Neoplasms / pathology* Magnetic Resonance Imaging* Male Middle Aged Neoplasm Staging / methods Predictive Value of Tests Prospective Studies Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Tomography, Emission-Computed* Tomography, X-Ray Computed* Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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