Document Detail


Non-randomized open trial of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in ten people with chronic epilepsy.
MedLine Citation:
PMID:  22342198     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This is a non-randomized open assessment of eicosapentaenoic acid (EPA) supplementation in ten people (five males) with refractory focal seizures. Each received 1000mg of EPA daily for 3months. Six people had fewer seizures during the supplementation period compared with baseline (range 12 to 59% reduction) and one other person had markedly reduced seizure severity. The mean reduction in seizure frequency was 16% (95% CI - 10% to 35%, p=0.26). With the small number of participants and open nature of the study, interpretation of the results is difficult, but a possible weak effect of EPA on seizures cannot be discounted. Further examination of EPA supplementation should be undertaken with larger numbers of people in controlled trials. Higher doses and longer duration of treatment should be considered.
Authors:
Alan W C Yuen; Dominique Flugel; Annkathrin Poepel; Gail S Bell; Janet L Peacock; Josemir W Sander
Related Documents :
409278 - Effect of deep surgical sepsis on protein-sparing therapies and nitrogen balance.
10361688 - Effect of media constituents on the formation by halophilic yeast of the 2 (or 5)-ethyl...
9802948 - Quantumchemical study of the catalytic triad in subtilisin: the influence of amino acid...
22415108 - Folic acid use and nonsyndromic orofacial clefts in china: a prospective cohort study.
8121248 - Effects of trans fatty acids on lipid accumulation in 3t3-l1 cells.
17742578 - Morphactin-induced parthenocarpy in the cucumber.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-17
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  -     ISSN:  1525-5069     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; Epilepsy Society, Chalfont St Peter, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Experimentally induced pain alters the EMG activity of the lumbar multifidus in asymptomatic subject...
Next Document:  Treatment of Bankart Lesions in Traumatic Anterior Instability of the Shoulder: A Randomized Control...