Document Detail


Non-random association between DNA markers and Huntington disease locus in the Italian population.
MedLine Citation:
PMID:  1683157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43. This observation increases the number of loci in linkage disequilibrium with HD. However, the amount of disequilibrium does not allow either a finer localization of the HD gene or a substantial improvement in risk calculations.
Authors:
A Novelletto; P Mandich; E Bellone; P Malaspina; G Vivona; F Ajmar; M Frontali
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  40     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-20     Completed Date:  1991-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  374-6     Citation Subset:  IM    
Affiliation:
Dipartimento di Biologia, Università Tor Vergata, Roma, Italy.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Chromosomes, Human, Pair 4
Gene Frequency
Genetic Markers*
Humans
Huntington Disease / genetics*
Italy
Linkage Disequilibrium*
Polymorphism, Restriction Fragment Length
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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