Document Detail

Non protein bound iron concentrations in amniotic fluid.
MedLine Citation:
PMID:  16009144     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. DESIGN AND METHODS: Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation. RESULTS: NPBI increased progressively from weeks 14--15 to weeks 15--16, peaking at 17--18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically significant regression coefficient with GA, bi-parietal diameter and transverse cerebellar diameter. CONCLUSIONS: The present data constitutes the first quantification of NPBI concentrations in amniotic fluid under physiological conditions. Correlations with GA and ultrasound fetal biometry suggest that NPBI may play a role in fetal growth.
D Gazzolo; S Perrone; P Paffetti; M Longini; P Vezzosi; M Bruschettini; M Lituania; G Buonocore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical biochemistry     Volume:  38     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  674-7     Citation Subset:  IM    
Department Paediatrics G. Gaslini, Children's University Hospital, 16148 Genoa, Italy.
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MeSH Terms
Amniotic Fluid / chemistry*
Chromatography, High Pressure Liquid
Iron / analysis*,  chemistry
Nitrilotriacetic Acid / chemistry
Pregnancy Trimester, Second / physiology
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/alpha-Fetoproteins; 139-13-9/Nitrilotriacetic Acid; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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