Document Detail


Non platinum metal complexes as anti-cancer drugs.
MedLine Citation:
PMID:  17315259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of metal complexes with platinum central atoms such as cisplatin or carboplatin had an enormous impact on current cancer chemotherapy. However, the spectrum of cancers that can be treated with platinum agents is narrow and treatment efficacy suffers from side effects and resistance phenomena. These unresolved problems in platinum-based anti-cancer therapy have stimulated increased research efforts in the search for novel non platinum-containing metal species as cytostatic agents. Preclinical and clinical investigations showed that the development of new metal agents with modes of action different from cisplatin is possible. Thus, complexes with iron, cobalt, or gold central atoms have shown promising results in preclinical studies and compounds with titanium, ruthenium, or gallium central atoms have already been evaluated in phase I and phase II trials. This review covers some relevant examples of preclinical and clinical research on novel non platinum metal complexes.
Authors:
Ingo Ott; Ronald Gust
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  340     ISSN:  0365-6233     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  117-26     Citation Subset:  IM    
Affiliation:
Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany. ottingo@zedat.fu-berlin.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / pharmacology*,  therapeutic use,  toxicity
Cobalt / pharmacology
Ferric Compounds / pharmacology
Ferrous Compounds / pharmacology
Gallium / pharmacology
Humans
Molecular Structure
Neoplasms / drug therapy*
Organogold Compounds / pharmacology
Organometallic Compounds / pharmacology*,  therapeutic use,  toxicity
Organoplatinum Compounds / pharmacology
Ruthenium Compounds / pharmacology
Titanium / pharmacology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Ferric Compounds; 0/Ferrous Compounds; 0/Organogold Compounds; 0/Organometallic Compounds; 0/Organoplatinum Compounds; 0/Ruthenium Compounds; 7440-32-6/Titanium; 7440-48-4/Cobalt; 7440-55-3/Gallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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