Document Detail

Non-pharmacological neuroprotection: role of emergency stroke management.
MedLine Citation:
PMID:  16651819     Owner:  NLM     Status:  MEDLINE    
Acute stroke should be considered a medical emergency, where actions taken in the first hours are fundamental for achieving recovery of the damaged cerebral tissue and a better prognosis for the patient. Recanalization and neuroprotective treatment has been used with mixed results. The effectiveness observed in the first hours with thrombolytic drug treatment is only applicable to a small percentage of patients, and attempts to widen this treatment window have not yet proved fruitful. Pharmacological neuroprotective treatment has not yet demonstrated the clinical effectiveness observed in experimental models. The concept of neuroprotection in cerebral ischemia also involves a series of mechanisms that take place at the cerebral level following vascular occlusion. In this context, it should be borne in mind that a series of physiological functions usually involved in the cerebral metabolism (control of blood pressure, of temperature, of glycemia and of arterial oxygen saturation) play a key role in modulation of the ischemic process. Changes in the control of these mechanisms may aggravate the process of cerebral damage in the first hours of ischemic stroke. In this work we review the prognostic importance of the main mechanisms that may influence the acute phase of cerebral ischemic stroke, as well as their therapeutic management and control in the clinical situation.
Rogelio Leira; Miguel Blanco; Manuel Rodríguez-Yáñez; José Flores; Jorge García-García
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-02
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  21 Suppl 2     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-02     Completed Date:  2007-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-98     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Department of Neurology, Division of Vascular Neurology, Stroke Unit, Hospital Clínico Universitario, Santiago de Compostela, Spain.
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MeSH Terms
Antihypertensive Agents / pharmacology,  therapeutic use
Blood Glucose / metabolism
Blood Pressure / drug effects
Body Temperature
Brain Ischemia / blood,  physiopathology,  therapy*
Clinical Trials as Topic
Emergency Medical Services*
Hypoglycemic Agents / therapeutic use
Hypothermia, Induced / methods
Meta-Analysis as Topic
Oxygen / blood
Oxygen Inhalation Therapy
Practice Guidelines as Topic
Stroke / blood,  physiopathology,  therapy*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Blood Glucose; 0/Hypoglycemic Agents; 7782-44-7/Oxygen

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