Document Detail


Non-pharmacological neuroprotection: role of emergency stroke management.
MedLine Citation:
PMID:  16651819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute stroke should be considered a medical emergency, where actions taken in the first hours are fundamental for achieving recovery of the damaged cerebral tissue and a better prognosis for the patient. Recanalization and neuroprotective treatment has been used with mixed results. The effectiveness observed in the first hours with thrombolytic drug treatment is only applicable to a small percentage of patients, and attempts to widen this treatment window have not yet proved fruitful. Pharmacological neuroprotective treatment has not yet demonstrated the clinical effectiveness observed in experimental models. The concept of neuroprotection in cerebral ischemia also involves a series of mechanisms that take place at the cerebral level following vascular occlusion. In this context, it should be borne in mind that a series of physiological functions usually involved in the cerebral metabolism (control of blood pressure, of temperature, of glycemia and of arterial oxygen saturation) play a key role in modulation of the ischemic process. Changes in the control of these mechanisms may aggravate the process of cerebral damage in the first hours of ischemic stroke. In this work we review the prognostic importance of the main mechanisms that may influence the acute phase of cerebral ischemic stroke, as well as their therapeutic management and control in the clinical situation.
Authors:
Rogelio Leira; Miguel Blanco; Manuel Rodríguez-Yáñez; José Flores; Jorge García-García
Related Documents :
3343299 - 19f imaging of cerebral blood oxygenation in experimental middle cerebral artery occlus...
10767499 - Intra-aortic administration of epinephrine above an aortic balloon occlusion during exp...
10851369 - Long-term changes of hemodynamics and metabolism after carotid artery occlusion.
22528409 - Fundamentals.
24960649 - The need to label red blood cell units with their haemoglobin content: a single centre ...
8059649 - Stroke risk after abrupt internal carotid artery sacrifice: accuracy of preoperative as...
7137869 - Simple and rapid method for the assessment of the oxygen affinity of haemoglobin.
1600779 - Carbon dioxide and oxygen partial pressure in expiratory water condensate are equivalen...
16424069 - Salvage of focal cerebral ischemic damage by transfusion of high o2-affinity recombinan...
Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-02
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  21 Suppl 2     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-02     Completed Date:  2007-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-98     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Affiliation:
Department of Neurology, Division of Vascular Neurology, Stroke Unit, Hospital Clínico Universitario, Santiago de Compostela, Spain. rleiram@meditex.es
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / pharmacology,  therapeutic use
Blood Glucose / metabolism
Blood Pressure / drug effects
Body Temperature
Brain Ischemia / blood,  physiopathology,  therapy*
Clinical Trials as Topic
Emergency Medical Services*
Humans
Hypoglycemic Agents / therapeutic use
Hypothermia, Induced / methods
Meta-Analysis as Topic
Oxygen / blood
Oxygen Inhalation Therapy
Practice Guidelines as Topic
Stroke / blood,  physiopathology,  therapy*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Blood Glucose; 0/Hypoglycemic Agents; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Deterioration in acute ischemic stroke as the target for neuroprotection.
Next Document:  Neuroprotection in malignant MCA infarction.